It is used to prevent breathing problems that happen with exercise. Excipient information presented when available (limited, particularly for generics); consult specific product labeling.Aerosol Powder Breath Activated, Inhalation: Serevent Diskus: 50 mcg/dose (28 ea, 60 ea) [contains lactose] Call your doctor for medical If adherence cannot be ensured, a fixed-dose combination product containing both an ICS and a LABA is recommended.• Bronchospasm: Paradoxical bronchospasm that may be life threatening may occur with use of inhaled agents; this should be distinguished from inadequate response. -Long-acting beta2-adrenergic agonists (LABA), such as this drug, as monotherapy without an inhaled corticosteroid (ICS) increase the risk of asthma-related death. Loxapine: Agents to Treat Airway Disease may enhance the adverse/toxic effect of Loxapine. Stiripentol: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). This is not a list of all drugs or health problems that interact with salmeterol. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.Oral inhalation: For oral inhalation only. Procarbazine prescribing information states that this combination should be avoided.QT-prolonging Agents (Highest Risk): QT-prolonging Agents (Indeterminate Risk - Caution) may enhance the QTc-prolonging effect of QT-prolonging Agents (Highest Risk). Of particular concern with nonselective beta-blockers or higher doses of the beta1 selective beta-blockers.Beta-Blockers (Nonselective): May diminish the bronchodilatory effect of Beta2-Agonists.Betahistine: May diminish the therapeutic effect of Beta2-Agonists.Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics.Clofazimine: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Cocaine (Topical): May enhance the hypertensive effect of Sympathomimetics.
Select one or more newsletters to continue. Consult drug interactions database for more detailed information.• Lactose: Powder for oral inhalation may contain lactose; use is contraindicated in patients with severe milk protein allergy.• Appropriate use: Asthma: Not indicated for the initial (rescue) treatment of acute episodes of bronchospasm. Long-acting beta2-adrenergic agonists (LABA), such as formoterol, increase the risk of asthma-related death. Uses of Salmeterol: It is used to treat asthma. In cases where use of an ICS and a LABA is clinically indicated, appropriate steps must be taken to ensure adherence with both treatment components. You may also report side effects at https://www.fda.gov/medwatch. Salmeterol is a long-acting β 2 adrenergic receptor agonist (LABA) used in the maintenance and prevention of asthma symptoms and maintenance of chronic obstructive pulmonary disease (COPD) symptoms. Studie ukázaly, že při samostatné aplikaci LABA a IKS mají někteří pacienti tendenci vysazovat IKS, protože kortikosteroidy nepřinášejí bezprostřední úlevu, charakteristickou pro bronchodilatancia. -A U.S. trial showed an increase in asthma-related deaths in subjects receiving this drug (13 deaths out of 13,176 subjects treated for 28 weeks on salmeterol versus 3 out of 13,179 subjects on …
Do not use salmeterol for patients whose asthma is adequately controlled on low- or medium-dose ICS.Available data from controlled clinical trials suggest that LABAs as monotherapy increase the risk of asthma-related hospitalization in pediatric and adolescent patients. When LABAs are used in fixed-dose combination with ICS, data from large clinical trials do not show a significant increase in the risk of serious asthma-related events (hospitalizations, intubations, death) compared to ICS alone.Use of salmeterol for the treatment of asthma as monotherapy without a concomitant ICS is contraindicated. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Before inhaling the dose, breathe out fully; do not exhale into the Diskus device; activate and use only in a level, flat position. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, Protect from direct heat or sunlight. Specifically, there may be an increased risk for pulmonary edema and/or dyspnea. Do not use with a spacer device or wash mouthpiece; Diskus should be kept dry.Store at 20°C and 25°C (68°F and 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).