The patient should be carefully monitored, since recurrences of NMS have been reported.Loxitane, like other antipsychotics, may impair mental and/or physical abilities, especially during the first few days of therapy. Loxitane administration to nursing women should be avoided if clinically possible.Safety and effectiveness of Loxitane in pediatric patients have not been established.Extrapyramidal Symptoms - Neuromuscular (extrapyramidal) reactions during the administration of Loxitane have been reported frequently, open during the first few days of treatment. Increased Mortality in Elderly Patients with Dementia-Related PsychosisElderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. These symptoms are usually not severe and can be controlled by reduction of Loxitane dosage or by administration of antiparkinson drugs in usual dosage.Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Daily dosage (in terms of base equivalents) should be adjusted to the individual patient’s needs as assessed by the severity of symptoms and previous history of response to antipsychotic drugs.Initial dosage of 10 mg twice daily is recommended, although in severely disturbed patients initial dosage up to a total of 50 mg daily may be desirable. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Metabolites are excreted in the urine in the form of conjugates and in the feces unconjugated.Loxitane is indicated for the treatment of schizophrenia. Symptoms of schizophrenia include: Hallucinations — imagined voices or images that seem real; Delusions — beliefs that are not true (e.g., other people are reading your … However, Loxitane and its metabolites have been shown to be transported into the milk of lactating dogs. Therefore, careful observation should be made for pigmentary retinopathy and lenticular pigmentation since these have been observed in some patients receiving certain other antipsychotic drugs for prolonged periods.Because of possible anticholinergic action, the drug should be used cautiously in patients with glaucoma or a tendency to urinary retention, particularly with concomitant administration of anticholinergic-type antiparkinson medication.Experience to date indicates the possibility of a slightly higher incidence of extrapyramidal effects following intramuscular administration than normally anticipated with oral formulations. This medicine should be taken with a full glass of water. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). It can reduce the desire to hurt yourself or others, encourage clear thinking and make you feel less nervous and less aggressive.Loxapine is not approved for use in dementia-related psychotic conditions.This information is for educational purposes only.
As would be expected from the pharmacologic actions of the drug, the clinical findings may range from mild depression of the CNS and cardiovascular systems to profound hypotension, respiratory depression, and unconsciousness. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias).The diagnostic evaluation of patients with this syndrome is complicated. Seizures have been reported in patients receiving Loxitane at antipsychotic dose levels, and may occur in epileptic patients even with maintenance of routine anticonvulsant drug therapy.Loxitane has an antiemetic effect in animals.