Every pregnancy is unique. You may take mirtazapine during pregnancy if you need it to remain well.
This suggests (although does not prove) that the small amounts of mirtazapine delivered to the baby in the breast milk may reduce the risk of any sort of withdrawal phenomena.Smit M, Wennink HJ, Heres MM, Dolman KK, Honig A. When deciding whether or not to use a medicine in pregnancy you need to weigh up how the medicine might improve your and/or your unborn baby’s health against any possible problems that the drug may cause.
However, the reported data are too scarce to come to a clear assessment of the risk of mirtazapine in lactation.No information is available on the use of mirtazapine in pregnancy and Poor Neonatal Adaptation Syndrome (PNAS) or neurobehavioral development at an age over one year.In conclusion, mirtazapine seems to be safe in pregnancy, especially regarding incidence of congenital malformations.
There might be an association between mirtazapine and spontaneous abortion, however, this might be attributable to underlying psychiatric disease.An increased risk of major neonatal malformations associated with mirtazapine in pregnancy has not been reported. Copyright 2018 MGH Center for Women's Mental Health | All Rights Reserved | Site Developed by Keep up with the latest news in women’s mental health and our research. Treatment and prevention options include antidepressant therapy. As many as 1 in every 5 pregnancies ends in a miscarriage, and 1 in 40 babies are born with a birth defect. Use is not recommended unless clearly needed. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. Most case reports have found that mirtazapine will get into breast milk in low amounts, and most nursing babies have not had any reported side effects from the medication.
Our bumps leaflets are written to provide you with a summary of what is known about use of a specific medicine in pregnancy so that you can decide together with your health care provider what is best for you and your baby. These are referred to as the background population risks. Limited available data, four papers on 11 exposed neonates, suggest that use of mirtazapine during breastfeeding is safe due to a low relative infant dose. But if your depression is not treated during pregnancy this can also increase the chance of problems. One study has shown that women taking sertraline during pregnancy were more likely to give birth early (before 37 weeks of pregnancy) and to have a low birth weight baby (<2500g). Although one study showed a nearly significant increase in occurrence of respiratory problems and hypoglycaemia, no indication of causality could be given. ScienceDirect ® is a registered trademark of Elsevier B.V.Mirtazapine in pregnancy and lactation – A systematic reviewCopyright © 2015 Elsevier B.V. and ECNP. Mirtazapine has been linked to a very small increased risk of problems for your unborn baby.
The incidence of PNAS after exposure to mirtazapine was much lower in infants who were partially or fully breastfed composed to those who were bottle fed (18.6% versus 54.5%, P = 0.024). AU TGA pregnancy category: B3 US FDA pregnancy category: C Comments:-Use of adequate methods of contraception should be encouraged.-If used during or shortly before birth, monitor newborn for discontinuation effects. It is unclear whether the increased risk of having a low birth weight baby was just because the babies were more likely to be born earlier, or whether sertraline might affect a baby’s growth in the womb.
This website is dedicated to providing reliable, evidence-based, and accurate information about use of medicines in pregnancy, in the form of freely available patient information leaflets called 'Bumps' ('Best Use of Medicines in Pregnancy'). However, if we add this study to previous reports, we now have about Of the 54 infants exposed to mirtazapine in the third trimester, 14 were diagnosed with poor neonatal adaptation syndrome (PNAS). Depression is common in pregnancy and associated with increased risk of adverse effects for the neonate. Although one study did show that babies exposed to mirtazapine in the womb were more likely to be preterm than those born to women who did not have depression or take any medicines, this … While we have adequate data to support the use of SSRI antidepressants during pregnancy, there is less data regarding other classes of antidepressants. In 31 papers a total of 390 cases of neonates exposed to mirtazapine during pregnancy or lactation have been described.