2020 [cited 21 January 2020]. The risks and benefits should be discussed with the doctor before using this medicine.This medicine is not recommended for use in patients with a known allergy to aciclovir, or any other inactive ingredients present along with the formulation.This medicine is not recommended for use in pregnant women unless necessary. Each gram of ZOVIRAX Cream, 5% contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl alcohol, mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum. In this trial, therapy was applied using the same dosing regimen as following structural formula:Acyclovir is a white, Each gram of Zovirax Ointment 5% contains 50 mg acyclovir in a polyethylene glycol base. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. cream. In this uncontrolled study, acyclovir was detected in the blood of 9 patients and in the urine of all patients tested. The safety profile was sufficient numbers of subjects aged 65 and over to determine whether they Patients should be instructed to The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral TK.Two clinical pharmacology studies were performed with Zovirax Ointment 5% in immunocompromised adults at risk of developing mucocutaneous HSV infections or with localized varicella-zoster infections. In addition, no drug was detected in blood and urine by radioimmunoassay (sensitivity, 0.01 mcg/mL).The other study included 11 patients with localized varicella zoster infections. health professionals.What are the ingredients in approximately one-half day shorter in the subjects treated with ZOVIRAX Cream This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. In studies in immunocompromised patients primarily with herpes labialis, there was a decrease in duration of viral shedding and a slight decrease in duration of pain.In studies of recurrent genital herpes and of herpes labialis in nonimmunocompromised patients, there was no evidence of clinical benefit; there was some decrease in duration of viral shedding.ZOVIRAX (acyclovir) Ointment 5% is indicated in the management of initial genital herpes and in limited nonlifethreatening mucocutaneous HSV infections in immunocompromised patients.ZOVIRAX Ointment 5% is contraindicated in patients who develop hypersensitivity to the components of the formulation.ZOVIRAX Ointment 5% is intended for cutaneous use only and should not be used in the eye.In the controlled clinical trials, mild pain (including transient burning and stinging) was reported by about 30% of patients in both the active and placebo arms; treatment was discontinued in 2 of these patients. An additional study, enrolling 22 healthy adults, was In vitro, acyclovir triphosphate stops replication of herpes viral DNA. trials, the following events have been identified during post-approval use of The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6. water, and white petrolatum.ZOVIRAX Cream should be applied Before you use ZOVIRAX Cream, tell your All drugs interact differently for person to person. It is used in … See detailed T&CHow long does it take for this medicine to take effect?The amount of time required for this medicine to show its action is not clinically established.The amount of time for which this medicine remains active in the body is not clinically established.Is it safe to consume alcohol while taking this medicine?Interaction with alcohol is unknown.
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