0000005778 00000 n ���$x�� ��}�� "9:�0��5"�(�{@d�� Nebivolol is a beta blocker used to treat high blood pressure and heart failure. 0000001601 00000 n 0000013220 00000 n
Serious side effects may include heart failure and bronchospasm. x�b```b``�a`e``cd@ A��%�@��g.o\vP{Q� ��5l�,��L��/�k�=�� v�mR�/Dz���os3�_��8����F%f�Ɂ�n,�"K���5K;[�l��S�l���pű)X}]]%)�hI������H�;G�I���r� ���]0��#��L���U��]zM����Z�א�r/� ��\`�u Nebivolol consists of a racemic mixture of two enantiomers: D-Nebivolol and L-Nebivolol. It may be used by itself or with other blood pressure medication. %PDF-1.4 %���� 1464 0 obj <> endobj Its use in pregnancy … It’s available as an oral tablet under the brand name Bystolic. 1489 0 obj<>stream Bystolic is contraindicated in patients with severe bradycardia, heart block greater than first degree, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome (unless a permanent pacemaker is in place), severe hepatic impairment (Child-Pugh > B) and in patients who are hypersensitive to any component of the product. It’s not available as a generic drug. 0000006539 00000 n
Nebivolol is extensively metabolized, partly to active hydroxy-metabolites.
Common side effects include dizziness, feeling tired, nausea, and headaches. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Nebivolol (hydrochloride) Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. trailer
Both enantiomers are rapidly resorbed following oral administration, regardless of the absence or presence of food. Ann Arbor, MI 48108 <<12E07F3D0A91514AA3E8E0EDAD42BEBF>]>>
Common side effects include dizziness, feeling tired, nausea, and headaches.Nebivolol was patented in 1983 and came into medical use in 1997.In a laboratory experiment conducted on biopsied heart tissue, nebivolol proved to be the most β1-selective of the Several studies have suggested that nebivolol has reduced typical beta-blocker-related side effects, such as Bystolic is associated with a number of serious risks. 0000005024 00000 n
0000003446 00000 n 0000001880 00000 n
0000009935 00000 n Nebivolol is a prescription drug. 0000000016 00000 n It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity). It is taken by mouth.
0000001392 00000 n xref 0000002739 00000 n This drug may be taken as part of a combination therapy … 0000002474 00000 n %%EOF Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. 0000007923 00000 n 0000005102 00000 n
1907/2006 as amended by (EC) No. 1464 26 0000010549 00000 n Nebivolol (hydrochloride) SAFETY DATA SHEET according to Regulation (EC) No. 0000002226 00000 n 0000004019 00000 n 0000007236 00000 n Bystolic therapy is also associated with warnings regarding abrupt cessation of therapy, cardiac failure, angina and acute myocardial infarction, bronchospastic diseases, anesthesia and major surgery, diabetes and hypoglycemia, thyrotoxicosis, peripheral vascular disease, non-dihydropyridine calcium channel blockers use, as well as precautions regarding use with Mylan Laboratories licensed the U.S. and Canadian rights to nebivolol from In India, nebivolol is available as Nebula (Zydus Healthcare Ltd), Nebizok (Eris life-sciences), Nebicip (Cipla ltd), Nebilong (Micro Labs), Nebistar (Lupin ltd), Nebicard (Torrent), Nubeta (InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2Baldwin CM, Keam SJ. 0000004769 00000 n As with other β-blockers, it is generally a less preferred treatment for high blood pressure. 1272/2008 1.1 Product Code: 23660 Section 1. 0 Nebivolol is a long-acting, cardioselective beta-blocker. 0000003981 00000 n 0000004520 00000 n 0000009212 00000 n Nebivolol: In the Treatment of Hypertension in the US. 0000008570 00000 n startxref 0000047368 00000 n
0000000836 00000 n 0000004263 00000 n