Tell your doctor about all your current medicines and any … Azelastine is oxidatively metabolized to the principal active metabolite, desmethylazelastine, by the cytochrome P450 enzyme system. Buy Astelin Nasal Spray Online 137mcg in 10ml without prescription and free shipping here… Astelin (Azelastine) provides relief from bothersome nasal symptoms such as congestion, itchy/runny nose, sneezing and post nasal drip due to seasonal … In animal reproduction studies, there was no evidence of fetal harm at oral doses approximately 5 times the clinical daily dose. No evidence of tumorigenicity was observed in rats at doses up to 30 mg/kg day (approximately 270 and 240 times the MRHDID for adults and children, respectively, on a mg/mAzelastine hydrochloride showed no genotoxic effects in the Ames test, DNA repair test, mouse lymphoma forward mutation assay, mouse micronucleus test, or chromosomal aberration test in rat bone marrow.There were no effects on male or female fertility and reproductive performance in male and female rats at oral doses up to 30 mg/kg (approximately 270 times the MRHDID in adults on a mg/mThe efficacy and safety of Astelin Nasal Spray were evaluated in three placebo-controlled clinical trials of Astelin Nasal Spray including 322 patients with seasonal allergic rhinitis who received two sprays per nostril twice a day for up to 4 weeks. Bitter taste was reported in 8.3% of patients compared to none in the placebo group. Do not give Astelin Nasal Spray to other people, even if they have the same symptoms that you have. Avoid spraying Astelin Nasal Spray into the eyes.Astelin Nasal Spray is a nasal spray solution. Version: 10.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This will help to keep the medicine from going into your throatWhen you finish using your Astelin Nasal Spray, wipe the spray tip with a clean tissue or cloth. Put the safety clip and dust cover back on the bottle.Do not allow a young child to use Astelin without help from an adult.Call your doctor if your symptoms do not improve, or if they get worse.Store this medicine in an upright position at room temperature. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively.In an embryo-fetal development study in mice dosed during the period of organogenesis, azelastine hydrochloride caused embryo-fetal death, structural abnormalities (cleft palate; short or absent tail; fused, absent or branched ribs), delayed ossification, and decreased fetal weight at approximately 300 times the maximum recommended human daily intranasal dose (MRHDID) in adults (on a mg/mIn an embryo-fetal development study in pregnant rats dosed during the period of organogenesis from gestation days 7 to 17, azelastine hydrochloride caused structural abnormalities (oligo-and brachydactylia), delayed ossification, and skeletal variations, in the absence of maternal toxicity, at approximately 270 times the MRHDID in adults (on a mg/mIn an embryo-fetal development study in pregnant rabbits dosed during the period of organogenesis from gestation days 6 to 18, azelastine hydrochloride caused abortion, delayed ossification and decreased fetal weight and severe maternal toxicity at approximately 530 times the MRHDID in adults (on a mg/mIn a prenatal and postnatal development study in pregnant rats dosed from late in the gestation period and through the lactation period from gestation day 17 through lactation day 21, azelastine hydrochloride produced no adverse developmental effects on pups at maternal doses up to approximately 270 times the MRHDID (on mg/mThere are no data on the presence of azelastine hydrochloride in human milk, the effects on the breastfed infant, or the effects on milk production.
Maximum plasma concentrations (CAzelastine hydrochloride administered intranasally at doses above two sprays per nostril twice daily for 29 days resulted in greater than proportional increases in CBased on intravenous and oral administration, the steady-state volume of distribution is 14.5 L/kg. Available for Android and iOS devices. We comply with the HONcode standard for trustworthy health information - These patients had vasomotor rhinitis for at least one year, negative skin tests to indoor and outdoor aeroallergens, negative nasal smears for eosinophils, and negative sinus X-rays. You may report side effects to FDA at 1-800-FDA-1088.Using Astelin with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Accordingly, Astelin Nasal Spray should be kept out of the reach of children.Astelin (azelastine hydrochloride) Nasal Spray, 137 micrograms (mcg), is an antihistamine formulated as a metered-spray solution for intranasal administration. Azelastine hydrochloride occurs as a white, almost odorless, crystalline powder with a bitter taste.