Its chemical name is (-)-1-([α] in 1.0N HCl (C = 5%) = -12.2° (-11.7° to -12.5°)Timolol maleate has a molecular weight of 432.50.
Timolol Maleate Ophthalmic Solution 0.25% timolol equivalent is supplied in a white low density polyethylene (LDPE) bottle with a controlled drop tip and a yellow polypropylene cap as follows: NDC 68682-812-05: 5 mL in a 7.5 mL capacity bottle In a subsequent study in female mice, in which post-mortem examinations were limited to the uterus and the lungs, a statistically significant increase in the incidence of pulmonary tumors was again observed at 500 mg/kg/day.The increased occurrence of mammary adenocarcinomas was associated with elevations in serum prolactin which occurred in female mice administered oral timolol at 500 mg/kg/day, but not at doses of 5 or 50 mg/kg/day.
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Although the risk of serious side effects is low when timolol is used in the eyes, side effects can occur if the medicine is absorbed into your bloodstream. 318 0 obj
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A slight reduction of resting heart rate in some patients receiving Timolol Maleate Ophthalmic Solution (mean reduction 2.9 beats/minute standard deviation 10.2) was observed.Timolol Maleate Ophthalmic Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.Timolol Maleate Ophthalmic Solution is contraindicated in patients with (1) bronchial asthma; (2) a history of bronchial asthma; (3) severe chronic obstructive pulmonary disease As with many topically applied ophthalmic drugs, this drug is absorbed systemically.Sympathetic stimulation may be essential for support of the circulation in individuals with diminished myocardial contractility, and its inhibition of beta-adrenergic receptor blockade may precipitate more severe failure.Patients with chronic obstructive pulmonary disease (e.g., chronic bronchitis, emphysema) of mild or moderate severity, bronchospastic disease, or a history of bronchospastic disease (other than bronchial asthma or a history of bronchial asthma, in which Timolol Maleate Ophthalmic Solution is contraindicated The necessity or desirability of withdrawal of beta-adrenergic blocking agents prior to major surgery is controversial. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-adrenergic blocking agents that might precipitate a thyroid storm.Because of potential effects of beta-adrenergic blocking agents on blood pressure and pulse, these agents should be used with caution in patients with cerebrovascular insufficiency.
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Timolol is a nonselective beta‐blocker, commonly used in dogs and cats for the treatment of glaucoma.17, 18 In 1 study, instillation of 1 drop of 0.5% timolol ophthalmic solution twice daily decreased heart rate (HR) in healthy cats by a mean of 17 bpm.19 Ophthalmic administration of timolol has been reported to decrease HR in healthy beagle dogs by 10%.20 318 32
M�� ��bm |n�am�x��-z�_��ϱ�b�� (timolol maleate ophthalmic solution) 0.5% is a non-selective beta-adrenergic receptor blocking agent indicated in the treatment of elevated intraocular pressure (IOP) in patients with ocular hypertension or open-angle glaucoma. Tonography and fluorophotometry studies in man suggest that its predominant action may be related to reduced aqueous formation. Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate.
Beta-adrenergic receptor blocking agents may mask the signs and symptoms of acute hypoglycemia.Beta-adrenergic blocking agents may mask certain clinical signs (e.g., tachycardia) of hyperthyroidism.
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She recovered without treatment but approximately two months later developed irregular heartbeat, hypertension, dizziness, tinnitus, faintness, increased pulse rate, and borderline first degree heart block.Timolol Maleate Ophthalmic Solution is available in concentrations of 0.25 and 0.5%. /SMask /None>>
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The pH of the solution is approximately 7.0, and the osmolarity is 260-340 mOsm/kg.