MAIN OUTCOME MEASURE(S): Serum concentrations of LH, FSH, and T before and after CC therapy, as well as clinical indicators of gonadal function. Nonbacterial pyospermia: a consequence of clomiphene citrate therapy. Oestrogen levels may be elevated owing to aromatization of testosterone. The mean (sd) duration of CC treatment was 19 (14) months. Semen parameters in this group also improved, and two of the three men achieved pregnancies with CC alone. OBJECTIVE: To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG). Serum estrogen was quite high at 72 pg/ml. Anti-oestrogens increase the production of GnRH. Impotence related to anabolic steroid use in a body builder. Department of Endocrinology and Key Laboratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. One of the most important reasons for this is that over training causes the hypothalamus in the brain to stop producing the master hormone GnRH. The self-administration of hCG should have elicited a testosterone response, but it is uncertain whether he received true hCG in adequate dosage. Decreased responses also occurred in men with diabetes, hypertension, coronary artery disease, and multiple medication use. He is a college student and a competitive body builder who had used anabolic steroids for eight months, alternating 16-week cycles of testosterone cypionate (Depo- Testosterone), 1,500 to 1,800 mg per week, and oxymetholone (Anadrol), 560 mg per week. Our study demonstrates that CC is efficacious after 3 years of therapy. CC-treated men who developed pyospermia were older than nonpyospermic men [pyospermic, 41.7 +/- 8.1 years; nonpyospermic, 35.6 +/- 4.9 years-P < .01). In this study we investigated the efficacy of clomiphene citrate in the treatment of hypogonadism with the objectives of raising endogenous serum testosterone (T) and improving the testosterone/estrogen (T/E) ratio. RESULT(S): Reversal of symptoms, normalization of T levels with LH surge, restoration of pituitary-gonadal axis. These endocrine parameters are of practical use in evaluating patients misusing androgenic anabolic steroids. Druginformer Identified Side Effects: Anger, Erectile dysfunction, Anxiety, Irritability, Mood altered, Restlessness Posted By Anonymous in askapatient.com on August 20, 2005 @ 12:00 am “ Side Effects: Our 5 year old son has been on zyrtec off and on since 1 y/o. Hypogonadism produced by functional suppression of pituitary gonadotropins has been shown to correct with clomiphene citrate, but with a modest effect on sexual function. According to the literature reports, this usually occurs within four months. PATIENT(S): A 29-year-old male who has run 50 to 90 miles per week since 15 years of age and who presented with a pelvic stress fracture, markedly decreased bone mineral density, and symptomatic hypogonadotropic hypogonadism. My T levels are great but ED is still severe ..there seem to be no known cause tried several specialists.Symptons Penile tissue shrinkage extremely poor arousal ..i guess effects of aging He had been running between 80 and 140 km a week since he was fifteen. (2) Clomid lowers bad cholesterol and raises good cholesterol (3) • The main outcome measures were predictors of response and long-term results with long-term CC therapy in hypogonadal patients. Infertility was the most common reason (64%) for seeking treatment. If judged by the testis volume, 52 patients (81.2%) were effective and 12 patients were ineffective. Men with anxiety-related disorders responded better to normalization of testosterone. It is most commonly treated by testosterone supplementation therapy but in younger patients this can lead to testicular atrophy with subsequent exogenous testosterone dependency and may impair spermatogenesis. 33 patients were treated with hCG 1500 IU intramuscularly twice a week, whereas 31 patients were treated with intramuscular hCG 1500 IU plus HMG 75 IU twice a week, for at least 6 months. Short-term clinical safety data for enclomiphene have been satisfactory and equivalent to safety data for testosterone gels and placebo.