Agrawal A(1), Nogar JN(2), Koenig S(3).
This site needs JavaScript to work properly. Based on pharmacological properties, LTG is a candidate for extracorporeal removal, however, the successful use of HD for the treatment of this poisoning is not well described. Unable to load your collection due to an error 2014 Dec;52(10):993-1004. doi: 10.3109/15563650.2014.973572. doi: 10.1080/15563650.2017.1370096. Adverse events after overdose include neurotoxicity in the form of sedation and seizure activity, as well as cardiopulmonary toxicity in the form of sodium-channel blockade and cardiovascular collapse. doi: 10.1080/15563650.2017.1370096. They are both commonly prescribed and therefore it is important to have an understanding of their pharmacokinetics and the … However, there are reported cases of … 2015 Jun;53(5):454-65. doi: 10.3109/15563650.2015.1035441.Toxicol Commun. Lamotrigine [LTG] is primarily an anti-epileptic drug used to treat seizure disorders, depression, and bipolar disease. Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. Electronic address:
[email protected]. Management of lamotrigine overdose using hemodialysis. Safety profile of lamotrigine in overdose Akintunde Alabi, Adam Todd, Andrew Husband and Joe Reilly Abstract Background: Lamotrigine is an anticonvulsant as well as a mood stabilizer. Am J Emerg Med. Name must be less than 100 characters The spectra of clinical effects of lamotrigine in acute overdose are not well established. Context: Lamotrigine is a broad-spectrum anticonvulsant commonly used to treat seizure and bipolar mood disorders. 2004 Nov;38(11):1811-5. doi: 10.1345/aph.1E192. Please enable it to take advantage of the complete set of features! (Q.1): Patient is stable on Lamotrigine but suddenly stopped it due to rash. Epub 2004 Sep 7.Clin Toxicol (Phila). Based on pharmacological properties, LTG is a candidate for extracorporeal removal, however, the successful use of HD for the treatment of this poisoning is not well described. […] In … We report the case of a 44 year-old female after a LTG overdose that experienced prolonged sedation that was ultimately treated with HD with an excellent response.We use cookies to help provide and enhance our service and tailor content and ads. doi: 10.1016/j.ajem.2019.05.026. There is no consensus regarding the role of hemodialysis (HD) in management of lamotrigine toxicity. COVID-19 is an emerging, rapidly evolving situation. It is generally well tolerated with limited side effects reported during routine use. If a patient has discontinued lamotrigine for a period of more than 5 half-lives, it is recommended that initial dosing recommendations and guidelines be followed. ScienceDirect ® is a registered trademark of Elsevier B.V.Management of lamotrigine overdose using hemodialysisScienceDirect ® is a registered trademark of Elsevier B.V. Lamotrigine may cause a serious skin rash that may cause you to be hospitalized or even cause death. 2011 Apr;49(4):330-3. doi: 10.3109/15563650.2011.572555.Ghannoum M, Laliberté M, Nolin TD, MacTier R, Lavergne V, Hoffman RS, Gosselin S; EXTRIP Workgroup.Clin Toxicol (Phila). Epub 2019 May 15.Ghannoum M, Yates C, Galvao TF, Sowinski KM, Vo TH, Coogan A, Gosselin S, Lavergne V, Nolin TD, Hoffman RS; EXTRIP workgroup.Clin Toxicol (Phila).
Lamotrigine can be restarted (without need for titration) within how many days of lamotrigine discontinuation? 2019;3(1):102-105. doi: 10.1080/24734306.2019.1699750. 2019 Aug;37(8):1603.e1-1603.e2.
The most common treatment of a lamotrigine overdose is supportive treatment, meaning that side effects and symptoms are managed as quickly as possible. Author information: (1)Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, Zucker School of Medicine at Hofstra/Northwell, New York, USA.