Therapeutic action: It relaxes the smooth muscles of the bronchioles allowing maximum passage of air. For comparison between groups, an unpaired Mann–Whitney rank-sum test was used.Time course of the acute bronchoprotective effects of single inhalations of: a) The effects of salbutamol and its enantiomers on the EAR and LAR are shown in figure 3Similar results were obtained when the immediate (maximal) increases in In week 1, all groups of animals received saline and developed comparable AHR to histamine, at both 5 h (after the EAR) and 23 h (after the LAR) after allergen challenge (fig. In the 1st week, all guinea pigs inhaled vehicle (saline) for 3 min, 30 min before and 5.5 h (between the EAR and LAR) and 23.5 h (after the LAR) after ovalbumin provocation.In the 2nd week, the animals were subdivided into four groups, inhaling either saline (control group), or A schematic illustration of the protocol is given in figure 1Schematic illustration of the study protocol. In week 1, all four groups of animals were subjected to vehicle (saline) inhalation, and, in week 2, to saline, For quantitative assessment of the EAR (0–5 h after allergen provocation) and LAR (8–23 h after allergen provocation), airway function was continuously monitored over the whole time-span. Other tremorogenic drugs, Tremor is a common complaint for many patients.
The side effects of salbutamol generally result from the drugs action on muscles such as cramps or tremors. Surprisingly, however, when administered 30 min before and 5.5 h after the allergen challenge, It could be argued, however, that the reduction in AHR after the EAR and LAR might yet be related to inhibition of histamine release during the EAR, since, in the same animal model, histamine HIt should be mentioned that, contrary to the general belief that short-acting β-agonists do not suppress the LAR, occasional reports have indicated that nebulised salbutamol is able to reduce the development of the LAR in asthmatic patients, not only at high The acute bronchoprotective effects of salbutamol and its enantiomers were measured before and 5 and 23 h after allergen provocation.
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, Systemic bioavailability of hydrofluoroalkane (HFA) formulations of fluticasone/salmeterol in healthy volunteers via pMDI alone and spacer, A novel breath-actuated integrated vortex spacer device increases relative lung bioavailability of fluticasone/salmeterol in combination, Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Bronchoprotection with formoterol via dry powder and metered-dose inhalers in patients with asthma, Pharmacological Approach to Evaluate Aerosol Pulmonary Deposition, Dose‐response to salbutamol via a novel palm sized nebuliser (Aerodose® Inhaler), conventional nebuliser (Pari LC Plus) and metered dose inhaler (Ventolin™ Evohaler™) in moderate to severe asthmatics, An investigation into the predictive value of cascade impactor results for side effects of inhaled salbutamol, This study evaluated the bronchoprotective effects of inhalation of therapeutically relevant doses of the racemate and individual enantiomers in guinea pigs.
15. Aim of the study was to determine sensitivity, reproducibility, reference values and the agreement with a questionnaire. At each visit patients inhaled the same nominal 1200 µg dose of salbutamol from the appropriate device.