Most adverse reactions reported during therapy with Norvasc were of mild or moderate severity. However for rats, litter size was significantly decreased (by about 50%) and the number of intrauterine deaths was significantly increased (about 5-fold) in rats receiving amlodipine maleate at a dose equivalent to 10 mg amlodipine/kg/day for 14 days before mating and throughout mating and gestation. Amlodipine is a calcium channel blocker that reduces blood pressure by dilating your blood vessels 1. The benefit of treating hypertension may outweigh any risks to the baby.Amlodipine can pass into breast milk, but effects on the nursing baby are not known. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The service is provided through a patient group direction, developed by our Independent Medical Agency who are registered with and regulated by the Care Quality Commission and the Regulation and Quality Improvement Authority – this is a means by which our specifically trained pharmacists can legally supply a prescription only medicine where appropriate.
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In a long-term (follow-up at least 6 months, mean 13.8 months) placebo-controlled mortality/morbidity study of Norvasc 5–10 mg in 1153 patients with NYHA Classes III (n=931) or IV (n=222) heart failure on stable doses of diuretics, digoxin, and ACE inhibitors, Norvasc had no effect on the primary endpoint of the study which was the combined endpoint of all-cause mortality and cardiac morbidity (as defined by life-threatening arrhythmia, acute myocardial infarction, or hospitalization for worsened heart failure), or on NYHA classification, or symptoms of heart failure. Titrate more rapidly, however, if clinically warranted, provided the patient is assessed frequently.The effective antihypertensive oral dose in pediatric patients ages 6–17 years is 2.5 mg to 5 mg once daily. Monitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A inhibitors to determine the need for dose adjustment No information is available on the quantitative effects of CYP3A inducers on amlodipine. Up to date, approved and regulated prescribing and patient information for licensed medicinesActive ingredients/generics: pyridoxine hydrochlorideActive ingredients/generics: colecalciferol; cholecalciferolFind the latest NHS prices, pack sizes and manufacturers on the NHS dictionary of medicines and devices (X-PILs are Patient Information Leaflets (PILs) that have been specifically created for people with sight problems.
This site uses cookies. In controlled clinical trials directly comparing Norvasc (N=1730) at doses up to 10 mg to placebo (N=1250), discontinuation of Norvasc because of adverse reactions was required in only about 1.5% of patients and was not significantly different from placebo (about 1%). Although the acute intravenous administration of amlodipine decreases arterial blood pressure and increases heart rate in hemodynamic studies of patients with chronic stable angina, chronic oral administration of amlodipine in clinical trials did not lead to clinically significant changes in heart rate or blood pressures in normotensive patients with angina.With chronic once daily oral administration, antihypertensive effectiveness is maintained for at least 24 hours. Norvasc is also used to treat high blood pressure (hypertension).
Patients with renal failure may therefore receive the usual initial dose.Elderly patients and patients with hepatic insufficiency have decreased clearance of amlodipine with a resulting increase in AUC of approximately 40–60%, and a lower initial dose may be required. Our specially-trained travel health pharmacists can provide advice and information on vaccinations and access to antimalarial medicines tailored to you and your trip. Effects were similar in black patients and in white patients.Two hundred sixty-eight hypertensive patients aged 6 to 17 years were randomized first to Norvasc 2.5 or 5 mg once daily for 4 weeks and then randomized again to the same dose or to placebo for another 4 weeks.