; Springmeyer, S.C.; Connor, J.D. Medical Letter 24: 55–56 (1982).Biron, K.K. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … and Woods, N.C.: Renal function after acyclovir intravenous injection. ; Straube, R.; Large, K.; Hintz, M.; Spector, S. and Connor, J.D. Antimicrobial Agents and Chemotherapy 21: 393–398 (1982b).Laskin, O.L. Abstracts of the 7th International Congress of Pharmacology, p. 354 (1978).de Miranda, P.; Krasny, H.C.; Page, D.A. : Double-blind controlled trial of topical acyclovir in genital herpes simplex virus infections. and Elion, G.B. ): 172–175 (Jul 1982a).Van Dyke, R.B. ): 182–185 (Jul 1982).Calabresi, P. and Parks, R.E.
: Perspectives on interactions of acyclovir with Ebstein-Barr and other herpes viruses. Twenty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, Miama, Abstract 414 (1982b).Wade, J.C.; Hintz, M.; McGuffin, R.W. ; Smith, H.A. and Brigden, D.: Acyclovir tolerance in humans. : Induction of both thymidine and deoxycytidine kinase activity by herpes virus. Two studies in human volunteers, however, suggest that hPEPT-1 may not be the sole or even primary transporter of valaciclovir. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein-Barr virus infection. ; Wyborny, C.; Hintz, M. and Keeney, R.E. and DeStefano, E.: Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine.
American Journal of Medicine 73 (Suppl. American Journal of Medicine 73 (Suppl.
However, this chemical change was associated with increased toxicity, possibly due to the accumulation of the phosphorylated forms of the parent compound. : Metabolic disposition of 9-(2-hydroxyethoxymethyl)guanine, a new antiviral drug. ; de Miranda, P.; Beauchamp, L. and Schaeffer, H.J. Early modifications included alteration in the purine ring. American Journal of Medicine 73 (Suppl. The exact mechanism of increased absorption with valaciclovir is not fully determined but probably involves intestinal dipeptide transporters, followed by rapid ester hydrolysis in the small intestine and liver. The distribution, intracellular kinetics, metabolism, and excretion of aciclovir after its entry into the systemic circulation are identical whether it is administered as oral aciclovir, oral valaciclovir, or intravenous aciclovir. Acyclovir has dose-independent kinetics. Journal of Chromatography 224: 51–58 (1981).Laskin, O.L.
; Connor, J.D. : Treatment of cytomegalovirus pneumonia with high-dose acyclovir. ): 7–13 (Jul 1982).Elion, G.B. and Liao, S.: Treatment of herpes virus infections in immunocompromised patients with acyclovir by continuous infusion. : Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. ): 197–201 (Jul 1982c).Laskin, O.L. ; Keller, P.M.; Furman, P.A. Soyoung Shin, Tae Hwan Kim, Da Young Lee, Seung Eun Chung, Jong Bong Lee, Do-Hyung Kim, Beom Soo Shin, Development of a Population Pharmacokinetics-Based in vitro-in vivo Correlation Model for Drugs with Site-Dependent Absorption: the Acyclovir Case Study, … ): 275–279 (Jul 1982).St. : Effect of renal failure on the pharmacokinetics of acyclovir. The acyclovir total body clearance (29 ml/min/1.73mThe pharmacokinetics of acyclovir in children (greater than 1 year of age) are similar to those in adults. The bioavailability of oral acyclovir is low and decreases with increasing dosage. : Single-dose pharmacokinetics of acyclovir.
The significant improvement in aciclovir AUC associated with valaciclovir often spares the use of intravenous aciclovir and reduces the frequency of administration, improving patient adherence.Corresponding author.
American Journal of Medicine 73 (Suppl. genital herpes).Aciclovir is absorbed slowly and incompletely from the human gastrointestinal tract. Analytical Biochemistry 98: 319–328 (1979).Saral, R.; Burns, W.H. ): 18–26 (Jul 1982).Park, N.; Paven-Langston, D.; McLean, S.L. Biochemistry Journal 117: 21p–22p (1970).Quinn, R.P. ; Rocco, L. and Lietman, P.S. Claire, M.H.