Common side effects include: upper respiratory tract infection; The dose of this medicine will be different for different patients. Azelastine, a phthalazine derivative, is an antihistamine and mast cell stabilizer available as a nasal spray for hay fever and as eye drops for allergic conjunctivitis. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Therefore, close monitoring is warranted in patients with a change in vision or with a history of increased intraocular pressure, glaucoma, and/or cataracts.Glaucoma and cataract formation were evaluated with intraocular pressure measurements and slit lamp examinations in a controlled 12-month study in 612 adolescent and adult patients aged 12 years and older with perennial allergic or vasomotor rhinitis (VMR). There is no known antidote to azelastine hydrochloride and fluticasone propionate nasal spray. Overall, 1% of patients in both the azelastine hydrochloride and fluticasone propionate nasal spray and placebo groups discontinued due to adverse reactions.Table 1 contains adverse reactions reported with frequencies greater than or equal to 2% and more frequently than placebo in patients treated with azelastine hydrochloride and fluticasone propionate nasal spray in the seasonal allergic rhinitis controlled clinical trials.In the above trials, somnolence was reported in <1% of patients treated with azelastine hydrochloride and fluticasone propionate nasal spray (6 of 853) or vehicle placebo (1 of 861) [The safety data described below in children 6-11 years of age reflect exposure to azelastine hydrochloride and fluticasone propionate nasal spray in 152 patients (6 to 11 years of age; 57% male and 43% female) with seasonal allergic rhinitis in one double-blind, placebo-controlled clinical trial of 2-week duration. Overall, less than 1% of the combined azelastine HCl nasal solution (nasal spray) groups discontinued due to adverse events.Table 2 contains adverse reactions reported with frequencies greater than or equal to 2% and more frequently than placebo in children 6 to 11 years of age treated with azelastine HCl nasal solution (nasal spray), 0.1% or azelastine HCl nasal solution (nasal spray), 0.15% in the controlled trial described above.In a 4 week clinical trial, 191 patients ages 6 months to 5 years with either seasonal and/or perennial allergic rhinitis were treated with either azelastine HCl nasal solution (nasal spray), 0.1% or azelastine HCl nasal solution (nasal spray), 0.15% one spray per nostril twice daily. Fifty-four patients (12%) treated with azelastine HCl nasal solution (nasal spray), 0.15% and 17 patients (7%) treated with mometasone nasal spray discontinued from the trial due to adverse events.During the post approval use of azelastine HCl nasal solution (nasal spray), the following adverse reactions have been identified. The specific P450 isoforms responsible for the biotransformation of azelastine have not been identified. Before you use azelastine hydrochloride and fluticasone propionate nasal spray, make sure your healthcare provider shows you the right way to use it.Remove the translucent plastic cap from the spray pump tip of the bottle. Dosage Forms and Strengths. For Azelastine, 1 spray per nostril two times per day is the most often recommended dose. You can ask your pharmacist or healthcare provider for information about Azelastine HCl Nasal Solution (Nasal Spray) that is written for health professionals.Inactive ingredients: sorbitol, sucralose, hypromellose, sodium citrate, edetate disodium, benzalkonium chloride, and purified water.Azelastine (a-ZEL-uh-steen) HCl Nasal Solution (Nasal Spray), 0.15%Figure A identifies the parts of your Azelastine HCl Nasal Solution (Nasal Spray) pumpRemove the violet dust cover over the tip of the bottle and the violet safety clip just under the “shoulders” of the bottle. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.