ANGIOTENSIN II RECEPTOR ANTAGONIST (ARB) DOSING: TOOL FOR SWITCHING BETWEEN AGENTS IN CANADA ©2018 Canadian Pharmacists Association The information provided is intended to help prescribers select an alternative agent from the angiotensin II receptor antagonist (ARB) class.
Max dose is 40 mg/day.
Online ahead of print.Liu X, Long C, Xiong Q, Chen C, Ma J, Su Y, Hong K.Clin Cardiol.
0000005003 00000 n Angiotensin II Receptor Blocker (ARB) - Comparable Dose Chart - Valsartan (Diovan®) 40 mg daily - Candesartan (Atacand®) 4 mg daily - Irbesartan (Avapro®) 75 mg daily - Losartan (Cozaar®) 25 mg daily - Olmesartan (Benicar®) 10 mg daily - Telmisartan (Micardis®) 20 mg daily #ARB #Equivalent #Conversion #Dosing #Doseage #Table #AngiotensinII #Receptor #Blocker The dose was doubled if BP after 1 month was > or = 140/90 mm Hg. 0000009888 00000 n 0000005114 00000 n 0000002207 00000 n 2018 Dec 1;178(12):1681-1690. doi: 10.1001/jamainternmed.2018.4749.Coca SG, Garg AX, Swaminathan M, Garwood S, Hong K, Thiessen-Philbrook H, Passik C, Koyner JL, Parikh CR; TRIBE-AKI Consortium.Nephrol Dial Transplant.
Drug comparisons based on potency 0000001076 00000 n 0000017755 00000 n Doses of ACE-inhibitors and ARBs equivalent to 10mg of Lisinopril 538 used to calculate the Lisinopril-dose equivalent for each subject. 0000023620 00000 n 0000113273 00000 n There are few studies comparing equivalent doses of ACE-inhibitors, for specific indications. er doses of ACEI or ARB may be required to effectively counter angiotensin II.8,9 Several trials have compared low versus high doses of these drugs, but the results have been conflicting. %PDF-1.4 %âãÏÓ It is recommended that the new dose should be reduced by 30-50% to allow for incomplete cross-tolerance. 38 0 obj <> endobj
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0000014621 00000 n 0000059290 00000 n In multivariable multilevel modeling, UN >0.52 g/L was independently associated with the risk of acute respiratory failure (OR, 3.54, 1.05-11.96). 0000004252 00000 n trailer All rights reserved. 0000017662 00000 n 444 0 obj <> endobj
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0000017337 00000 n ACEI/ARB use was independently associated with acute kidney injury, AKI stage ≥1 (OR, 3.28, 2.17-4.94). Dosage adjustment not required; biliary excretion increases in renal dysfunction.
Reference 539 540 1.
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Please enable it to take advantage of the complete set of features! Pharmacist’s Letter/Prescriber’s Letter. 0000062613 00000 n doi: 10.1002/clc.23421. HTN: Start with 5 mg/day if CrCl 10-30 mL/minute. 3,813 patients with BP > or = 140/90 mm Hg who were not being treated with an ACEI or ARB were enrolled. Contraindication to ACEI or ARB-Already receiving ACEI or ARB. 0000001669 00000 n
0000000016 00000 n Read more for examples of scenarios that warrant or do not warrant emergent echo.
0000003503 00000 n 0000068748 00000 n Target doses and dose equivalents for ACEIs and ARBs were derived from European Society of Cardiology guidelines for the diagnosis and treatment of acute and CHF. Approximate Dose Equivalence Maximum Daily Dose (mg) Losartan (Cozaar®) 1: 50mg: 100mg: Candesartan (Atacand®) 1: 8mg: 32mg: Eprosartan (Teveton®) 600mg: 800mg: Irbesartan (Avapro®) 2: 150mg: 300mg: Telmisartan (Micardis®) 2: 40mg: 80mg: Valsartan (Diovan®) 2: 80mg: 160mg (160mg BID evaluated in heart failure studies) 0000025915 00000 n
Published by Oxford University Press for the Infectious Diseases Society of America. Free PMC article This site needs JavaScript to work properly. 0000059475 00000 n 0000067631 00000 n