Semen analysis was normal in most parameters in 8 patients as was testicular hormonal function. DNA contents were determined in rat liver and testis cells to illustrate the mutagenic effect of cyclosporine A and how the royal jelly can modulate this effect. ScienceDirect ® is a registered trademark of Elsevier B.V.Sperm abnormality toxicity due to cyclosporine A and the ameliorative effect of royal jelly in male rats© 2017 The Egyptian German Society for Zoology. 2010 Feb;139(2):439-45. doi: 10.1530/REP-09-0077. We will study the long term effects of low, therapeutic doses of CsA on spermatogenesis, Leydig cell and Sertoli cell functions, and fertility. 2020 Apr 20;20(1):54. doi: 10.1186/s12902-020-0533-6.Kadir RE, Ibrahim A, Ibrahim BA, Gwadabe SM, Jaji-Sulaimon R, Adigun MF, Oyewopo AO.Int J Reprod Biomed. Please enable it to take advantage of the complete set of features! In addition, TP ameliorated the nephrotoxicity of CsA. Epub 2019 Apr 5.Cell Transplant. Abnormal heads contained amorphous head and banana-shaped head, whereas the abnormal tails included divided and coiled tails. Impairment Of Fertility. 2009 Feb 25;7:19. doi: 10.1186/1477-7827-7-19.
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Male fertility in cyclosporine-treated renal transplant patients. From these results we concluded that cyclosporine A toxicity was dose and time dependent and should be administrated under special precautions and medical supervision.
Fertility and potential fertility were evaluated in 9 young men on cyclosporine A therapy following renal transplantation. Epub 2016 Sep 30.Caneguim BH, Cerri PS, Spolidório LC, Miraglia SM, Sasso-Cerri E.Reprod Biol Endocrinol. Use In Specific Populations Pregnancy Risk Summary Colson SN, Wyatt FB, Johnston DL, et al. Patients may be reassured that taking oral retinoids, cyclosporine, azathioprine, and tumor necrosis factor alpha inhibitors should not affect their fertility. CsA was taken up by both the tubular and intersititial compartments of the testis. 2015 Oct 21;10:136. doi: 10.1186/s13023-015-0332-8.Palomba S, Sereni G, Falbo A, Beltrami M, Lombardini S, Boni MC, Fornaciari G, Sassatelli R, La Sala GB.World J Gastroenterol. Of 4 men who had attempted to impregnate their wives 3 succeeded. Animals were divided into a control (untreated), 3 groups treated intraperitoneally with 20, 40 and 60 m/kg cyclosporine A for 5, 10 and 15 days, respectively and 3 groups treated intraperitoneally with 20, 40 and 60 mg/kg of cyclosporine A plus 100 mg/kg royal jelly administrated orally. The immunosuppressive drug, utilized widely in Egypt, cyclosporine A was studied to evaluate its toxicity in male rats. COVID-19 is an emerging, rapidly evolving situation. In preliminary studies using a rat model we have shown that CsA has deleterious effects on the testis. However, there has been no thorough investigation of the effects of CsA on the male reproductive system.
Cyclosporine A does not seem to affect adversely fertility in men. 2019 May 16;5(4):216-226. doi: 10.1016/j.ijwd.2019.05.002. We will also investigate the effects of androgen therapy on the nephrotoxic effects of CsA. Wiley Impairment of Fertility No impairment in fertility was demonstrated in studies in male and female rats receiving oral doses of cyclosporine up to 15 mg/kg/day (approximately 2,000 times the human daily dose of 0.001 mg/kg/day normalized to body surface area) for 9 weeks (male) and 2 weeks (female) prior to mating. The effect of cyclosporine (CsA) on fertility has assumed greater importance with the increasing numbers of pediatric transplantations being performed all over the world. COVID-19 is an emerging, rapidly evolving situation. eCollection 2020 Mar.Hassan AA, Abdoon ASS, Elsheikh SM, Khairy MH, Gamaleldin AA, Elnabtity SM.Environ Sci Pollut Res Int.
It also induced an insignificant effect on the total sperm counts after 5 days of injection with the drug combined with royal jelly.
Cyclosporine lowered serum testosterone despite an elevation of LH, indicating that the drug directly inhibited testosterone synthesis. Cyclosporine A does not seem to affect adversely fertility in men.