The overall results of this study indicate that the pharmacokinetics of enalapril in hypertensive children aged 2 months to ≤16 years are consistent across the studied age groups and consistent with pharmacokinetic historic data in healthy adults.In a clinical study involving 110 hypertensive pediatric patients 6 to 16 years of age, patients who weighed <50 kg received either 0.625, 2.5 or 20 mg of enalapril daily and patients who weighed ≥50 kg received either 1.25, 5, or 40 mg of enalapril daily. A few cases of lithium toxicity have been reported in patients receiving concomitant enalapril maleate and lithium and were reversible upon discontinuation of both drugs.
The effects appear to be similar in patients with renovascular hypertension.When given together with thiazide-type diuretics, the blood pressure lowering effects of enalapril maleate are approximately additive.In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril maleate. The possibility of hypotensive effects with enalapril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with enalapril. Following administration of enalapril maleate, there is an increase in renal blood flow glomerular filtration rate is usually unchanged.
Es importante tomar la medicación todos los días a la misma hora así como seguir las instrucciones y pedir ayuda si hay algún apartado que no se entienda. Other causes of volume depletion such as vomiting or diarrhea may also lead to a fall in blood pressure; patients should be advised to consult with the physician.Patients should be told not to use salt substitutes containing potassium without consulting their physician.Patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of neutropenia.Female patients of childbearing age should be told about the consequences of exposure to enalapril maleate tablets during pregnancy.
Sustancias. Enalapril is used to treat high blood pressure (hypertension) in adults and children who are at least 1 month old.. Enalapril is also used to treat congestive heart failure (CHF). Effects on exercise tolerance, heart size, and severity and symptoms of heart failure were observed in placebo-controlled studies lasting from eight weeks to over one year.In a multicenter, placebo-controlled clinical trial, 2,569 patients with all degrees of symptomatic heart failure and ejection fraction ≤35 percent were randomized to placebo or enalapril and followed for up to 55 months (SOLVD-Treatment).
Hemodynamic effects were observed after the first dose and appeared to be maintained in uncontrolled studies lasting as long as four months.
Enalapril is an ACE inhibitor.ACE stands for angiotensin converting enzyme.
In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms.
Patients should be so advised and told to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician.Patients should be cautioned to report lightheadedness, especially during the first few days of therapy. In general, avoid combined use of RAS inhibitors. In this study, enalapril maleate was generally well tolerated.In the above pediatric studies, enalapril maleate was given as tablets and for those children and infants who were unable to swallow tablets or who required a lower dose than is available in tablet form, enalapril was administered in a suspension formulation (see Enalapril maleate tablets USP are indicated for the treatment of hypertension.Enalapril maleate tablets USP are effective alone or in combination with other antihypertensive agents, especially thiazide- type diuretics.