opioid dose during the treatment phase were withdrawn from study. The survival of animals treated with 16.8 μg/kg GBP was determined and compared with control animals.
pms-Gabapentin: Gabapentin belongs to the class of medications called anti-epileptics.
Received more than $2,000 a year from a company for either of the last 2 years: Augusto Caraceni, Pfizer Italy; Ernesto Zecca, Pfizer Italy; Cinzia Martini, Pfizer Italy.Abbreviations: SD, standard deviation; NSAID, nonsteroidal anti-inflammatory drug.NOTE.
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In each of the main experiments, the rats were divided approximately equally between ‘treatment’ and ‘control’ groups. (B) Time courses of primary tumour development (dashed and solid lines, gabapentin and control saline application, respectively).
Serial passaging enabled the generation of a series of isogenic cell lines with markedly different metastatic potential.
Seven patients (8.8%) were withdrawn because of increased daily opioid dose for insufficient pain relief. Three concentrations of GBP were used: 4.6, 9.1 and 16.8 μg/kg (GBP1, GBP2 and GBP3, respectively).
One extra dose of opioid medication was available as needed (p.r.n.)