sulphonylureas or meglitinides).The tablet shells may be present in the faeces. Uncontrolled diabetes during pregnancy (gestational or permanent) is associated with increased risk of congenital abnormalities and perinatal mortality.A limited amount of data from the use of metformin in pregnant women does not indicate an increased risk of congenital abnormalities.
• Hepatic insufficiency, acute alcohol intoxication, alcoholismLactic acidosis, a very rare, but serious, metabolic complication, most often occurs at acute worsening of renal function or cardiorespiratory illness or sepsis. • Decrease of vitamin B12 absorption with decrease of serum levels during long-term use of metformin. • A decision to re-evaluate therapy is also required if the patient subsequently implements improvements to diet and/or exercise, or if changes to the medical condition will allow increased lifestyle interventions to be possible. However, as only limited data are available, breastfeeding is not recommended during metformin treatment. No prospective comparative data for metformin on macrovascular outcomes in patients with IGT and/or IFG and/or increased HbAPublished risk factors for type 2 diabetes include: Asian or black ethnic background, age above 40, dyslipidaemia, hypertension, obesity or being overweight, age, 1st degree family history of diabetes, history of gestational diabetes mellitus, and polycystic ovary syndrome (PCOS).Consideration must be given to current national guidance on the definition of prediabetes.Patients at high risk should be identified by a validated risk-assessment tool.The prospective randomised (UKPDS) study has established the long-term benefit of intensive blood glucose control in overweight type 2 diabetic patients treated with immediate release metformin as first-line therapy after diet failure. Metformin is contraindicated in patients with GFR<30 mL/min and should be temporarily discontinued in the presence of conditions that alter renal function, see section 4.3.Patients with heart failure are more at risk of hypoxia and renal insufficiency. Take your doses with meals. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.This survey is being conducted by the WebMD marketing sciences department.All information will be used in a manner consistent with the WebMD Other risk factors for lactic acidosis are excessive alcohol intake, hepatic insufficiency, inadequately controlled diabetes, ketosis, prolonged fasting and any conditions associated with hypoxia, as well as concomitant use of medicinal products that may cause lactic acidosis (see sections 4.3 and 4.5).Patients and/or care-givers should be informed of the risk of lactic acidosis. • Inhibitors of OCT1 (such as verapamil) may reduce efficacy of metformin. Plasma protein binding is negligible. A decision on whether to discontinue breast-feeding should be made, taking into account the benefit of breast-feeding and the potential risk to adverse effect on the child.Fertility of male or female rats was unaffected by metformin when administered at doses as high as 600 mg/kg/day, which is approximately three times the maximum recommended human daily dose based on body surface area comparisons.Metformin monotherapy does not cause hypoglycaemia and therefore has no effect on the ability to drive or to use machines.However, patients should be alerted to the risk of hypoglycaemia when metformin is used in combination with other antidiabetic agents (e.g. Metformin works by reducing the amount of glucose made by the liver and by making it easier for glucose to enter into the tissues of the body. https://www.webmd.com/drugs/2/drug-11294/glucophage-oral/details A slow increase of dose may improve gastro-intestinal tolerability.
If you notice other effects not listed above, contact your doctor or pharmacist.Call your doctor for medical advice about side effects.