Clinical pharmacology and patient studies support the clinical utility of guaifenesin in respiratory conditions where mucus hypersecretion is prevalent: acute upper respiratory tract infections (URTIs), stable chronic bronchitis, and possibly rhinosinusitis. Respir Res. High blood pressure often has no symptoms. Copyright © 2004 by the American Academy of Family Physicians.Copyright © 2020 American Academy of Family Physicians. 1999;54:23–7.Yuta A, Baraniuk JN. Important information. 21 CFR 341. 2010;363:2233–47.Rogers DF. Chest. Chest. National Ambulatory Medical Care Survey: 2013 State and National Summary Tables 2013. Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines. Bull Physiopathol Respir. Guaifenesin increases the volume and reduce the viscosity of tenacious sputum and is used as an expectorant for productive cough. It has been postulated that guaifenesin exerts its expectorant activity via a neurogenic mechanism: a stimulation of vagal afferent nerves in the gastric mucosa activates the gastro-pulmonary reflex, and increases the hydration of airway mucus [The viscoelastic behavior of bronchial mucus has important consequences for mucociliary clearance. Therapeutic approaches to mucus hypersecretion. You should not use Cardizem if you have very low blood pressure, a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), or … 1999;14:452–67.Martin C, Frija-Masson J, Burgel PR. Maintain fluid intake of 1500– 2000 mL/day to decrease viscosity of secretions. 1973;63:9–14.Parvez L, Vaidya M, Sakhardande A, Subburaj S, Rajagopalan TG. Rocky Mountain Poisons & Drugs Center Surveillance Report, 1991–2008, data on file. Mucus Hyperconcentration as a unifying aspect of the chronic Bronchitic phenotype. We describe recent advances in the understanding of guaifenesin’s mechanism of action and briefly discuss the rationale for its use in the context of its pharmacology, pharmacodymanics, and clinical efficacy profile.The respiratory tract is covered with a layer of mucus, which maintains airway humidification and acts as a protective barrier to inhaled particles and microorganisms. There are no other sources of funding to declare.Florida International University, Herbert Wertheim College of Medicine, 11200 SW 8th St., GL 495, Miami, FL, 33199, USAAlbert Einstein College of Medicine and Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY, 10461, USAReckitt Benckiser, LLC, 399 Interpace Parkway, Parsippany, NJ, 07054, USAYou can also search for this author in 1971;26:331–9.Naito SI, Mizutani M, Osumi S, Mikawa T, Sekishiro K, Nakao K, et al. Respir Care. 2014. In Martindale: The Complete Drug Reference. Targeting mucus hypersecretion: new therapeutic opportunities for COPD? Role of guaifenesin in the management of chronic bronchitis and upper respiratory tract infections. Guaifenesin, a mucoactive drug, acts by loosening mucus in the airways and making coughs more productive. Chest. tachicardia tremors. Edited by Sweetman S: The Pharmaceutical Press; 2016.Kagan L, Lavy E, Hoffman A. Federal Register 54 p. 8494–8509.Fahy JV, Dickey BF. This includes prescription and over-the-counter medicines, vitamins, and herbal products.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. Am J Forensic Med Pathol. Some studies showed evidence of efficacy based on improvements in subjective measures as patients assessed their cough, mucus clearance, or chest congestion symptoms. This will help generate the up-to-date and high-quality data needed to optimize guaifenesin’s effectiveness in established uses, and in new respiratory indications associated with mucus hypersecretion.Respiratory conditions have been known throughout most of recorded medical history, and today mortality and morbidity associated with respiratory conditions represent a substantial global health burden.
Despite its wide use for the symptomatic management of chest congestion and cough associated with acute upper respiratory tract infections (URTIs), such as the common cold, guaifenesin’s precise mechanism of action has not been fully elucidated.The use of guaifenesin as a natural remedy dates back to the 1500s, when guaiac tree extracts were used by Native Americans to treat various illnesses (Table The purpose of this article is to review scientific evidence for the use of guaifenesin in different respiratory conditions and to summarize the key clinical studies.