Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Read the Medication Guide available from your pharmacist. work) is imipramine hydrochloride. 0781-1762-01, If a satisfactory response does not occur within one week, increase the dose to 50 mg nightly in children under 12 years; children over 12 may receive up to 75 mg nightly. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. There were suicides in the adult trials, but the number was not sufficient to reach any conclusion about drug effect on suicide.It is unknown whether the suicidality risk extends to longer-term use, i.e., beyond several months. If signs of toxicity occur at anytime during this period, extended monitoring is required. Some conditions may become worse when the drug is abruptly stopped. The potentiation of adverse effects can be serious, or even fatal. It is designated 5-[3-(Dimethylamino) propyl]-10, 11-dihydro-5Imipramine hydrochloride, USP is a white to off-white, odorless, or practically odorless crystalline powder. 0781-1764-13, The pooled analyses of placebo-controlled trials in adults with MDD or other psychiatric disorders included a total of 295 short-term trials (median duration of 2 months) of 11 antidepressant drugs in over 77,000 patients. If you are 65 or older, use this medicine (imipramine tablets) with care. Endogenous depression is more likely to be alleviated than other depressive states. These risk differences (drug-placebo difference in the number of cases of suicidality per 1000 patients treated) are provided in No suicides occurred in any of the pediatric trials. ECG changes of unknown significance have been reported in pediatric patients with doses twice this amount.In the literature, there were four well-controlled, randomized, double-blind, parallel group comparison clinical studies done with imipramine in the elderly population. However, many people have no side effects or only have minor side effects. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
This is manifested by reduced litter size, a slight increase in the stillborn rate, and a reduction in the mean birth weight.Read the Medication Guide that comes with you or your family member’s antidepressant medicine. Hyperpyretic crises or severe convulsive seizures may occur in patients receiving such combinations. 0781-1766-13,
It is strongly recommended that the physician contact the local poison control center for specific pediatric treatment.Lower dosages are recommended for elderly patients and adolescents. These are not all of the side effects that may occur. Psychiatric referral may be appropriate.The principles of management of child and adult overdosages are similar. Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. You will need to talk about the benefits and risks of using this medicine (imipramine tablets) while you are pregnant. Limit your time in the sun. Consult your doctor or pharmacist if you have any questions. Such monitoring should include daily observation by families and caregivers.Antidepressant Medicines, Depression and other Serious Mental Illnesses, and Suicidal Thoughts or ActionsTalk to your, or your family member’s, healthcare provider about:What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions?Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions.