Doses above 200 mg/day should be given in … The findings were corroborated by two smaller open-label studies (N=31 combined) in the same patient population. Each intravenous dose should be infused over 1 hour. The median dose was 200 mg/day. Caution should be exercised when this drug is administered in this patient population. Specimens for fungal cultures and other relevant laboratory studies (wet mount, histopathology, serology) should be obtained before therapy to isolate and identify causative organisms.
Other substances that either share this metabolic pathway or modify CYP3A4 activity may influence the pharmacokinetics of itraconazole. (see Itraconazole is excreted in human milk; therefore, the expected benefits of SPORANOXThe long-term effects of itraconazole on bone growth in children are unknown. We comply with the HONcode standard for trustworthy health information - Do not drive or operate machinery until you know how SPORANOX affects you.Call your doctor for medical advice about side effects.
(See Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Itraconazole clearance decreases at higher doses due to saturable hepatic metabolism.Itraconazole is rapidly absorbed after oral administration. Itraconazole is excreted mainly as inactive metabolites in urine (35%) and in feces (54%) within one week of an oral solution dose. Caution should be exercised when this drug is administered in this patient population.
The observed absolute oral bioavailability of itraconazole is about 55%.The oral bioavailability of itraconazole is maximal when SPORANOXItraconazole exposure is lower with the Capsule formulation than with the Oral Solution when the same dose of drug is given. (400 mg/day) for 1 week. The median duration before discontinuation of therapy was 81 days (range: 2 to 776 days). Before you start any new medicine, ask your healthcare provider or pharmacist if it is safe to take it with SPORANOX.Taking SPORANOX with certain medicines may affect each other. More severe signs of parental toxicity, including death, were present in the next higher dosage level, 160 mg/kg/day (20 times the MRHD).Itraconazole was found to cause a dose-related increase in maternal toxicity, embryotoxicity, and teratogenicity in rats at dosage levels of approximately 40-160 mg/kg/day (5-20 times the MRHD), and in mice at dosage levels of approximately 80 mg/kg/day (10 times the MRHD). Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following an oral capsule dose. Caution should be exercised when this drug is administered in this patient population. As a consequence of non-linear pharmacokinetics, itraconazole accumulates in plasma during multiple dosing. The terminal half-life of itraconazole generally ranges from 16 to 28 hours after single dose and increases to 34 to 42 hours with repeated dosing.
Life-threatening conditions: may give loading dose of 200mg three times daily for 1 st 3 days; treat for at least 3 months until resolved. Several of these reports included concurrent administration of quinidine which is contraindicated (see Itraconazole showed no evidence of carcinogenicity potential in mice treated orally for 23 months at dosage levels up to 80 mg/kg/day (approximately 10 times the maximum recommended human dose [MRHD]). Select one or more newsletters to continue. Itraconazole is an inhibitor of the drug transporters P-Although many of the clinicaldrug Interactions in Table 1 are based on information with a similar azole Itraconazole is mainly metabolized through CYP3A4. Caution should be exercised when this drug is administered in this patient population.
Several of these reports included concurrent administration of quinidine which is contraindicated (see Because hypochlorhydria has been reported in HIV-infected individuals, the absorption of itraconazole in these patients may be decreased.Limited data are available on the use of oral itraconazole in patients with renal impairment. For patients responding to therapy, clinical response will be seen in 2 to 4 weeks. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.This is not a complete list of medicines that can interact with SPORANOX. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. The clinical course of histoplasmosis in HIV-infected patients is more severe and usually requires Analyses were conducted on data from an open-label, “single-patient-use” protocol designed to make itraconazole available in the U.S. for patients who either failed or were intolerant of amphotericin B therapy (N=190).
Itraconazole has been shown to cross the placenta in a rat model. (see Limited data are available on the use of oral itraconazole in patients with hepatic impairment.