Stopping glycolysis at the start sounds intentional. the observed amino acid depletion. I’ve saved years of my blood tests since sometimes my doctors find it useful to see them.My creatinine levels have always been on the low side of normalSorry I should have written creatine is low and not creatinine.Just had the lowest level of creatinine on my blood test from 2 weeks ago. It’s like another catch 22.In classic “nature health”, high protein consumption is considered to be highly inflammatory… :-(. Vomiting is the forcible emptying of the stomach in which the stomach has to overcome the pressures that are normally …
If this was solvable through common supplements, we would all know by now.And so this article does not make any suggestion on what to DO about these problems. I’ll have to find good estimates on the percentage and distribution of in brain (as opposed too in the CSF bag) extracellular fluid in order to get a better idea of it’s importance, role and potential handles to influence it.I’ll revisit the topics of MCT, MAS (and it’s potential vulnerability to ROS) and calcium pumps but it’ll take plenty of time and rereading to have sufficient understanding of it in order to put it to use.
Or if people with fast twitch muscles do any better with ME/CFS than without? Our bodies could be playing possum. Just a little bit has significant effects.Caffeine is also a modest or better bronchodilator, making you breath more easily.
I’ve noticed that I have a tendency to eat more ahorn syrup and honey and still get no sugar spikes from them. Once GTP drops too low the cofactor (BH4) for metabolising phenylalanine/tyrosine becomes depleted and fumarate/succinylCoA production via this route becomes compromised. But avoiding blood sugar peaks can go a long way too here IMO.There is another strongly overlooked potential source of energy here IMO: citrate. Just be modest in amounts, half a coffee spoon can do a lot!Forgot to mention: I suggest honey or agave syrup dissolved in water because it will contain more minerals, enzymes and vitamins compared to cola.
The intent of this blog is to demonstrate that researchers are understanding more and more about this condition. Try to get these aminoacids from whole foods (not protein shakes!!). I think cort was talking about Naviaux (and Ron) looking at ‘exosomes’ (intercellular signaling envelopes of cell contents), which sound very promising to me. Fast oxidizers on the other hand broke down glucose into pyruvate too fast and thus the Krebs energy cycle was limited by the breakdown of fat (glucose + fat, or pyruvate + acetate) is required in the Krebs cycle.Don’t you think patients with ME/CFS have tried going the route of hair and blood mineral tests and correction of their deficiencies based on the results? To maintain proper dopamine, creatine and succinyl-CoA levels in presence of of crappy Krebs cycle (regardless of the source of that inhibition which can be anything including oxidative stress), I combine tyrosine/phenylalanine with SAMe (or carnitine or methionine) when at the same time avoiding threonine, valine and isoleucine in order to avoid increased propionyl-CoA levels.Note that the strategy above puts pressure on GTP levels. But that would be the next mystery to solve. This is my experience, over 50 years.
I use about 4 gr of coffee per cup of 200 ml. The question becomes how to rebalance NAD(P)(H) levels. Cells as close as a few mm apart or less could see vastly different conditions to live and work in depending on where they are connected to the blood flow.
The information found on Health Rising is mostly put together by people with ME/CFS and/or FM.
It could be toxic if ingested by mouth as zinc oxide can be poisonous to the human body. But I agree that NAD(P)(H) imbalances could be key in ME/CFS as Naviaux’s data pointed towards NADPH and Maureen Hanson’s metabolomics data pointed to a redox imbalance.