isoniazid side effects liver rebetol

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© 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Rebetol is used in combination with other medicines to treat adults with long-term hepatitis C (a disease of the liver due to infection with the hepatitis C virus). (PDF/851.13 KB) Avoid alcohol while taking isoniazid. (PDF/830.56 KB) (PDF/856.76 KB) (PDF/97 KB) (PDF/726.48 KB) (PDF/868.95 KB)

(PDF/907.62 KB) & Katzung, B. Severe and sometimes fatal hepatitis has been reported with Some side effects of isoniazid / pyrazinamide / rifampin may occur that usually Check with your health care professional if any of the following side effects Isoniazid: The most frequently reported side effects are those affecting the nervous system and liver.Pyrazinamide: The most frequently reported side effects are those affecting the liver.Rifampin: The most frequently reported side effects are Common prodromal symptoms of severe/fatal hepatitis included anorexia, fatigue, malaise, nausea, vomiting, and weakness.Mild and transient transaminase elevations usually occurred in the first 4 to 6 months of treatment with isoniazid, and enzyme levels typically returned to normal without patients needing to discontinue treatment.Cerebral hemorrhage and fatal cerebral hemorrhage have occurred in patients who have continued or resumed treatment with rifampin after the appearance of purpura.Polyneuritis associated with isoniazid (e.g., muscle weakness, loss of tendon reflexes, paresthesia) was unlikely to occur at the recommended daily dose of this combination drug.High doses of isoniazid have resulted in convulsions and toxic encephalopathy.Thrombocytopenia with/without purpura usually occurred with intermittent rifampin treatment or upon resumption of interrupted treatment, but was typically reversible if the drug was discontinued as soon as purpura occurred.Flu syndrome usually occurred in patients taking intermittent rifampin regimens; however, this side effect has also occurred in patients taking rifampin irregularly and in those resuming treatment after a drug-free interval.1. The doses of phenytoin may need to be adjusted when given with isoniazid.Isoniazid may increase the plasma levels of theophylline. dark urine. Use during breastfeeding is likely safe. (PDF/865.06 KB) If you have a rare inherited blood condition called porphyria. (PDF/92.46 KB)

(PDF/890.1 KB) Both theophylline and isoniazid levels should be monitored.Valproate levels may increase when taken with isoniazid. Rifater (isoniazid / pyrazinamide / rifampin)." (PDF/100.67 KB) Cerner Multum, Inc. "UK Summary of Product Characteristics." (PDF/874.8 KB) Liver damage is more likely to occur in patients over 50 years of age. (PDF/869.46 KB) (PDF/869.46 KB) Combination treatment including Rebetol was effective in around a quarter of the adults whose disease had come back after previous treatment or whose previous treatment did not work, and over half of the children and adolescents treated.In the studies on triple therapy in patients with type 1 hepatitis C and compensated liver disease, ribavirin in combination with peginterferon alfa 2b and boceprevir was shown to be more effective than the dual combination with peginterferon alfa 2b alone.

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Rebetol is taken with food each day in two divided doses (morning and evening).

(PDF/92.46 KB) (PDF/125.1 KB) Alcohol can also cause isoniazid side effects to get worse. (PDF/850.25 KB) Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. (PDF/123.52 KB) It is unclear if use during pregnancy is safe for the baby.

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(PDF/96.22 KB) Prev INH hepatic injury or reaction; acute liver dz; pancreatitis. Katzung & Trevor's Pharmacology: examination & board review (10th ed., p. 417). (PDF/127.66 KB) (2013).

Adverse effects and adherence to treatment of rifampicin 4 months vs isoniazid 6 months for latent tuberculosis: a retrospective analysis. (PDF/99.79 KB)