The strong CYP3A4/PgP inhibitor ketoconazole led to significant increases in both AUC and C max values for alitretinoin.
It is used along with exercise, diet, and weight loss to decrease elevated lipid levels.
... All generic drug interactions for ketoconazole oral (lists will include brand and generic names): 29 contraindicated drug interactions;
A number of drugs are known to inhibit OATP1b1 (eg, clarithromycin, erythromycin, cyclosporine, ketoconazole, many protease inhibitors, gemfibrozil) and are known to increase simvastatin concentrations. Clinical Drug Interactions Source: Medscape from WebMDDisclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The CYP3A4 ± PgP substrates of simvastatin and ciclosporin A did not affect the single or repeated dose PK of alitretinoin.
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These medicines may interact and cause very harmful effects.
6.Jacobson TA.
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Ketoconazole side effects. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username To avoid this, it may be recommended to separate your … Severity of interaction:
Get emergency medical help if you have signs of an allergic reaction (hives, fever, chest pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling)..
The study is created by eHealthMe based on reports of 1,280 people who take Simvastatin and Meclizine from the Food and Drug Administration (FDA), and is updated regularly.
Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.
Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.Serious.
Administration of ranolazine in combination with diltiazem or simvastatin was safe and well tolerated during the interval studied.
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This tool may not cover all possible drug interactions.
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Contraindicated. ketoconazole oral will increase the level or effect of simvastatin oral by altering drug metabolism.
The interactions of ranolazine, a new antianginal compound, with inhibitors and substrates of the CYP3A isoenzyme family were studied in 1 open‐label and 4 double‐blind, randomized, multiple‐dose studies. doctor or pharmacist) know right away that you are taking these medicines together.
Background: Co-administration of cytochrome P450 (CYP) 3A4 inhibitors with simvastatin or atorvastatin is associated with increased risk of developing myopathy or rhabdomyolysis.
This work was supported by CV Therapeutics Inc, Palo Alto, California.Use the link below to share a full-text version of this article with your friends and colleagues.
Ketoconazole is predicted to moderately increase the exposure to fesoterodine.
Learn about drug interactions between ketoconazole oral and simvastatin oral and use the RxList drug interaction checker to check drug combinations. Simvastatin did not affect ranolazine pharmacokinetics, although ranolazine increased the AUC and CPlease check your email for instructions on resetting your password.