Martindale: the complete drug reference. It kills insects (parasites) that live on humans, such as head lice, the scabies mite and crab lice. Malathion in low doses (0.5% preparations) is used as a treatment for: Head lice and body lice.Malathion is approved by the US Food and Drug Administration for treatment of pediculosis.
It mostly affects persons in resource-poor countries, where prevalence can exceed 50 percent. Because of the sensitivity of RBC AChE to malathion exposure, most regulatory bodies have selected it as the endpoint for use in risk assessment, to be protective of other endpoints of concern.
Richards AG. Available from the pharmacy. Effect of organic phosphorus compounds and alkylating agents on the rat fetus.
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London: The Pharmaceutical Press; 1999:1407-8.52. Hazardous Substances Data Bank (database). 9th ed.
The Merck index.
Aqueous malathion 0.5% as a scabicide: clinical trial. Malathion inhibition of esterases as a determinant of malathion toxicity.
Budavari S, O’Neil MJ, Smith A et al, eds. 12. Silverton N. Malathion-resistant pediculosis capitis.
If someone swallows some of it by accident, go to the accident and emergency department of your local hospital.
Mathieu ME, Wilson BB.
Pediculosis and scabies are caused by ectoparasites. Centers for Disease Control and Prevention. Jones KN, English JC.
Malathion side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives ; difficult breathing; swelling of …
For Child. Ramu A, Slonim AE, London M et al. From the FDA web site (http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309shampoolbl.pdf). Use of malathion in the treatment of lousy children. Permethrin is generally the treatment of choice for head lice and scabies, because of its residual effect. Machin MGA, McBride WG.
Arthropod bites and stings. Distribution of malathion in body tissues and fluids. 13. New York: John Wiley & Sons; 1977:27-65.24. Phenothrin lotion, the latest recruit in the battle against headlice: the results of two controlled comparative studies. Available for Android and iOS devices.
Two applications of treatment with malathion liquid are needed, one week apart. Head lice cannot jump or fly but walk from one head to another. Resistance to malathion in a strain of body lice from Burundi.
Comparative trial of treatment with Prioderm lotion and Kwellada shampoo in children with head lice. Lindane Shampoo, USP, 1% prescribing information. 14. The adherent cylindrical nit structure and its chemical denaturation in vitro: an assessment with therapeutic implications for head lice. Gosselin RE, Smith RP, Hodge HC et al. Malathion percutaneous absorption after repeated administration to man. Whitehouse Station, NJ: Merck & Co., Inc; 1996:5740.4. 78.
Burgess I, Robinson RJ, Robinson J et al. 54. 32nd ed. Malathion carboxylesterase titer and its relationship to malathion toxicity.
66. Elk Grove Village, IL: American Academy of Pediatrics; 2006.63. The 2 most widely used treatments for scabies are permethrin cream and malathion lotion (brand name Derbac M). Case reports: limited effectiveness of charcoal hemoperfusion in malathion poisoning.
Malathion Lotion is often effective for patients with scabies as well as other patients suffering from other insect related conditions like head lice. Burkhart CG, Burkhart CN, Burkhart KM. Treating head lice. Malathion is not genotoxic in vivo, and it does not have an adverse impact on reproduction. From: HSDB.