Among the oils and surfactants studied, ImwitorPeer review under responsibility of Shenyang Pharmaceutical University.We use cookies to help provide and enhance our service and tailor content and ads. School of Pharmacy Bandung Institute of Technology, Ganesha 10, 40132, Bandung, Indonesia.Author to whom correspondence should be addressed.
Purpose: To develop and validate a dissolution test method for tablets containing 80 mg of drotaverine hydrochloride (DRT) and 250 mg of mefenamic acid (MEF). Incorporation of TW in the preparation of ternary dispersion systems resulted in a further increase in MFA dissolution. The objective of this study was to develop an immediate release dose form containing 250 mg Mefenamic acid (MFA) presented as a crystalline solid dispersion in order to achieve improved consistency in drug release through a simplified formulation compared to a commercial product. The dissolution medium consisted of 900 ml of phosphate buffer (pH 6.8) containing 0.25% w/v … The purpose of this study was to enhance the dissolution of mefenamic acid (MFA) through the formation of solid dispersion systems, and to compare the dissolution of the unformulated dispersions with those of formulated dispersions in tablets.
10-14-2008, 07:07 PM #2. rafli. Mefenamic acid has less biological half life (t1/2) of 2hrs and being an NSAID has a major side effect of gastric irritation. The clear solution was cooled in a −20 °C freezer and held at this temperature until the Mefenamic acid was crystallized. The mefenamic acid solubility predicted using COSMO-RS with reference solubility method showed a small MSE value of less than 2%. Published by Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. As stated in the USP, the dissolution of mefenamic acid from the mefenamic acid capsules in 45 min should be not less than 80%. in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Solid dispersions of MFA were prepared in polyethylene glycol 3350 (PEG) as a binary system, and PEG and Tween 20 (TW) as a ternary system by the melt method. 3, pp. Multiple requests from the same IP address are counted as one view. Production and hosting by Elsevier B.V.ScienceDirect ® is a registered trademark of Elsevier B.V. Articles in this Issue were published by another publisher The dispersions were characterized by dissolution, scanning electron microscopy, and powder x-ray diffraction studies. Indonesian Pharmacopeia V ed. Formulating such drug into nanoparticles using biocompatible polymers is expected to increase the sustain release action and to improve patient compliance with fewer side effects.
Received: 5 September 2015 / Accepted: 15 December 2015 / Published: 14 February 2016 Mefenamic Acid Standard solution ... (3:1) to obtain a solution having aHeavy metals, Method II 〈231〉: 0.002%.
The dissolution of mefenamic acid, in 0.05 M Tris buffer (pH 9.0) with 1% (w/v) SLS according to USP monograph for mefenamic acid capsules, from SEF was compared with that of mefenamic acid powder and commercial product . ScienceDirect ® is a registered trademark of Elsevier B.V.Pharmaceutics, Drug Delivery and Pharmaceutical TechnologyImproving Consistency for a Mefenamic Acid Immediate Release Formulation© 2020 American Pharmacists Association®. Materials and Methodology Mefenamic acid and Ethyl cellulose were obtained …
Mefenamic acid was blended with Eudragit ® E PO at drug loadings of 20%, 25%, 30%, and 40% using a V-shell blender (GlobePharma, Maxiblend ®, New Brunswick, NJ). To enhance the dissolution of poorly soluble mefenamic acid, self-emulsifying formulation (SEF), composing of oil, surfactant and co-surfactant, was formulated. (FI) adopted the USP method. Find support for a specific problem on the support section of our website. NURHIKMAH W, SUMIRTAPURA YC, PAMUDJI JS. You seem to have javascript disabled. Method procedure. (1998). By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. It is clearly seen that the dissolution… Please let us know what you think of our products and services.