Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Its structural formula is:Mercaptopurine Tablets USP are available in tablet form for oral administration. In mice, surviving female offspring of mothers who received chronic low doses of Mercaptopurine during pregnancy were found sterile, or if they became pregnant, had smaller litters and more dead fetuses as compared to control animals.1. Monitor the CBC and adjust the dose of Mercaptopurine Tablets for excessive myelosuppression Aminosalicylates (e.g., mesalamine, olsalazine or sulfasalazine) may inhibit the TPMT enzyme, which may increase the risk of myelosuppression when co-administered with Mercaptopurine Tablets. Due to the immunosuppression associated with maintenance chemotherapy for ALL, response to all vaccines may be diminished and there is a risk of infection with live virus vaccines. * It can be used as mild sedative given to people prior to surgery to help them relax. Adjust the dosage to maintain absolute neutrophil count (ANC) at a desirable level and for adverse reactions Use the lowest recommended starting dosage for Mercaptopurine Tablets in patients with hepatic impairment. Hepatosplenic T-cell lymphoma has been reported in patients treated with Mercaptopurine for inflammatory bowel disease (IBD), an unapproved use. This crisis results from clonidine rebound or rebound hypertension, a condition in which the lowered blood pressure caused by clonidine use suddenly rises.
Consult immunization guidelines for immunocompromised patients.Mercaptopurine Tablets can cause fetal harm when administered to a pregnant woman. In a series of 28 women receiving Mercaptopurine after the first trimester of pregnancy, 3 mothers died prior to delivery, 1 delivered a stillborn child, and 1 aborted; there were no cases of macroscopically abnormal fetuses.Mercaptopurine was embryo-lethal and teratogenic in several animal species (rat, mouse, rabbit, and hamster) at doses less than the recommended human doseThere are no data on the presence of Mercaptopurine or its metabolites in human milk, the effects on the breastfed child, or the effects on milk production. You may report side effects to the FDA at 1-800-FDA-1088.Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health.
Each scored tablet contains 50 mg Mercaptopurine and the following inactive ingredients: corn starch, hypromellose, lactose (anhydrous), lactose monohydrate, magnesium stearate, potato starch, sodium starch glycolate and stearic acid.Each tablet meets the requirements of Test 2 for Dissolution in the USP monograph for Mercaptopurine Tablets USP.Mercaptopurine is a purine analog that undergoes intracellular transport and activation to form metabolites including thioguanine nucleotides (TGNs). OSHA. Call your oncology care team if you are unable to keep fluids down for more than 12 hours or if you feel lightheaded or dizzy at any time. With facilities across the United States and trained advisors ready to answer your call, we are equipped and ready to help you get the treatment you deserve. If ventricular fibrillation is … Potential Side Effects of Clonidine The presence of medical personnel is important at this stage to make certain the preexisting condition is under control while tapering off from the clonidine.Until the dosage levels reach zero and the clonidine is out of the patient's system, starting new medication may be difficult unless it's compatible with the clonidine use.It's important that a patient begins treatment for clonidine withdrawal as early as possible. The hepatotoxicity has been associated in some cases with anorexia, diarrhea, jaundice and ascites. TGNs and other Mercaptopurine metabolites are also inhibitors of de novo purine synthesis and purine nucleotide interconversions. �p�������D�ٳ�1��5ڝ�+� 2�C�% �Kuo$b�;�3�BԾ�Ġ��TK� [See USP Controlled Room Temperature.] Dispense in a tight, child-resistant container as defined in the USP/NF.Mercaptopurine Tablets is a cytotoxic drug. Adverse reactions occurring in < 5 % of patients included urticaria, hyperuricemia, oral lesions, increased transaminases, hyperbilirubinemia, hyperpigmentation, infections, and pancreatitis. symptoms, although some fatigue may be present. There are reports of deaths attributed to hepatic necrosis associated with the administration of Mercaptopurine. Mercaptopurine may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. Adjust the dose to maintain absolute neutrophil count (ANC) at a desirable level and for adverse reactions Use the lowest recommended starting dosage for Mercaptopurine Tablets in patients with hepatic impairment.