Once the MFR is verified as 100% correct, it can be used to prepare formulations.The pharmacy must develop a system to secure and protect its MFRs. (3)What are homogenizers (aka electric mortar and pestle) used for?What are hot plates and magnetic stirrers used for?Save time by continuously stirring mixture in order to dissolve and mix ingredients.What are 2 important records that each compounded product must have?If a patient reports an ADR to a compounded product, where would a pharmacist record that information?Grinding powder into smaller, finer particles (can be done with mortar and pestle).Similar to trituration except a liquid (wetting/levigating agent) is added to help with grinding process to turn solid into uniform paste (can be incorporated into ointment/suspension).What should be obtained if a substance for compounding comes from a non-FDA registered facility?What should be done if a component does not have an exp date?Pharmacist will assign a conservative (cautious) date that is What are glidants/lubricants used for and give 2 examples.What are surfactants used for in powders and give an example.When 2 components are mixed together, they will melt at a lower temp than the melting temp of the individual components causing them to become sticky (may use adsorbent powder).What are adsorbent powders used for and give 2 examples.What are plasticizers used for and give 2 examples.Name bases used for hard, soft, and chewable lozenges?- Contain <20% water and >50% oil (least water content).Thickest ointments and used as protective barriers.What is commonly used for transdermal drug delivery of a gel?What is included in oil-soluble and water-soluble suppository bases?Compare and contrast the 3 methods to preparing a suppository.What lubricants can be applied to make it easier to remove suppositories?Reduce surface tension to help 2 compounds that resist each other move closer together.What is a wetting/levigating agent in regards to surfactants?Surfactant used to reduce surface tension between a solid particle (insoluble drug) and a liquid.Surfactant used to reduce surface tension between oil and water.Prevent degradation from oxygen, light, moisture and masks unpalatable taste.Provides color to product and sometimes correlates with flavor.What are diluents (fillers) and give example(s) for liquids (1) and dry products (6).Add size to very small dosages; for liquids can help suspend drug and disintegrate it.Softens and soothes skin/mucous membranes, provides barrier, and acts as drug delivery vehicle. Pharmacy compounding is the art and science of preparing personalized medications for patients.
This second individual should independently verify all of the information on the MFR and perform calculations independently of its creator.
These may include, among others, medical literature, professional organizations, hospitals, physicians, and other compounding pharmacies. For all of these reasons, pharmacists and technicians must assure that CRs are always accurate and complete.Sign up for free email updates to receive the latest news about products, services and events from MEDISCA. Compounding non-sterile products. Stephanie Montoya, CPhT. The CR is used to determine what ingredients were contained in the preparation that a particular patient received, which is important in case of a recall. The compounding pharmacist's best source for detailed information needed to grow and maintain a compounding practice. Here at Pharma 1 we can compound any non-sterile preparation your doctor orders. The CR is used during the preparation to guide and record the actual process. The CR is used to perform a final check of the preparation. The CR documents a patient-specific preparation.
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Non-Sterile Compounding.
A MFR is very similar to a CR.
Email. Spell. Provide protective layer to prevent drug dissolution in stomach instead of small intestine and may mask poor taste.What are flavoring agents (sweeteners) and give 7 examples.Give sweetness to preparation and may mask bitter taste.What are gelling/thickening agents (stabilizers) and give 10 examples.Prevent preparation from drying or becoming brittle.Has high miscibility with water used to dissolve solutes.Has low/no miscibility with water used to dissovle solutes.What are preservatives and give example(s) for oral (1), topical/nasal (1), and ophthalmic (5).What are the temperate ranges for room, refrigerator, and freezer?What is the beyond-use-date for nonaqueous formulations (e.g.
As previously noted, the CR is the primary document a pharmacy uses to determine which preparations contained a particular lot of ingredients in case of a recall. As such CRs should be readily available.
For example, the CR will list the lot numbers, expiration dates and weights of all the actual ingredients used, the names of the persons preparing and checking the formulation and … The standards were developed to address a need for more oversight over the quality and …
Regardless of the source of the formulation, the pharmacy must use a consistent format for its MFRs.MFR’s may be electronic or paper, but either form should contain:A MFR is often a complex and detailed document.
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