Olmi P, Cefaro GA, Balzi M, et al: Radiotherapy in the aged.Clin Geriat Med 13:143-168, 1997.33. However, patients receiving adjuvant therapy were younger than those observed. Aging 9:297-303,1997.48. Ann Surg217:430-438, 1993.26. J Clin Oncol15:2403-2413, 1997.43. Gut35:467-470, 1994.66. Anesth Analg 56:1-5, 1977.63. Ahlgren JD: Gastrointestinal cancer in the elderly.Gastroenterol 15:627-639, 1999.34. Diet The link of diet and the development of pancreatic cancer is still unclear. Endoscopy30:553-558, 1998.74. Wasil T, Lichtman SM, Gupta V, et al: Radiation therapy incancer patients 80 years of age and older. The authors recommended that patients with elevated bilirubin levels should be started at a reduced dose of gemcitabine (800 mg/mOther forms of chemotherapy, as well as novel agents, are being assessed in an ongoing series of phase II and III trials. Kamisawa T, Yuyang T, Egawa N, et al: Characteristics ofpancreatic carcinoma in the elderly. Family history of pancreatic cancer; Obesity; Older age, as most people are diagnosed after age 65; A large study demonstrated that the combination of smoking, long-standing diabetes and a poor diet increases the risk of pancreatic cancer beyond the risk of any one of these factors alone. However, no studies are available that adequately address this issue.Kamisawa et al examined the pathologic features of pancreatic cancer in 89 elderly patients (> 70 years) and compared them to 184 younger patients. [1] As the elderly population increases, oncologists will be faced with a progressively larger number of older patients with cancer. Boston,Jones and Bartlett Publishers, 1995.56. In fact, 90% are older than 55 and 70% are older than 65. Niederhuber JE, Brennan MF, Menck HR: The National CancerDatabase report on pancreatic cancer. Cancer 85:1261-1268,1999.44. J Jpn Panc Soc8:506-515, 1993.13. Klaassen DJ, MacIntyre JM, Cotton GE, et al: Treatment oflocally unresectable cancer of the stomach and pancreas: A randomized comparisonof 5-fluorouracil alone with radiation plus concurrent and maintenance5-fluorouracil-An ECOG study.
Gastrointest Endosc 37:31-37, 1991.71. Patients may be treated with prophylactic gastrojejunostomy at the time of initial laparotomy without increased mortality. J Clin Oncol 3:373-378, 1985.36. This article will review the existing literature on the presentation and surgical and medical treatment of pancreatic cancer in elderly patients.Several studies have shown that older patients are less likely to be staged than younger patients. [2,3] Among those who are staged, it appears that older patients present with earlier-stage disease. Venook AP, Egorin MJ, Rosner GL, et al: Phase I andpharmacokinetic trial of gemcitabine in patients with hepatic or renaldysfunction: Cancer and Leukemia Group B 9565. In a phase III study, 126 patients with unresectable pancreatic cancer were randomized to either weekly 5-FU at 600 mg/mMost patients who received gemcitabine had stable disease, but three achieved a partial response (overall response rate: 5.4%).
[15] Overall perioperative mortality was 6%. Pancreatic cancer almost always strikes over the age of 45, with about two-thirds of cases occurring in people over the age of 65. It is slightly more common in men than in women.
Semin Oncol 23:220-228, 1996.42.
Cameron JL, Pitt, HA, Yeo CJ, et al: One hundred andforty-five consecutive pancreaticoduodenectomies without mortality. [2] According to the National Cancer Database, 68.5% of pancreatic cancers were diagnosed in those over age 65 years. Int J Radiat Oncol Biol Phys 40:93-99, 1998.31. SUNDAY, March 31, 2019 -- Need another reason to stay slim?