It is used to relieve the symptoms of diarrhea that starts suddenly and lasts for a few days.
2018 Oct 4;2018:1360486. doi: 10.1155/2018/1360486. The dosage for adults is 4 mg (two caplets or four teaspoonfuls) after the first loose bowel movement. Free PMC article This product may produce darkening of the stool and tongue from the bismuth component, but this is harmless.
The action of naloxone suggests, but does not prove, that loperamide exerts its effect via opiate receptors.
A lower dosage is recommended for children. Mechanism of Action Acts directly on circular and longitudinal intestinal muscles, through the opioid receptor, to inhibit peristalsis and prolong transit time; reduces fecal volume, increases viscosity, and diminishes fluid and electrolyte loss; demonstrates antisecretory activity.
Loperamide is an opioid whose action is almost completely restricted to the gut. This action is analogous to that of morphine and codeine.
If needed, 2 mg can be used after each additional loose bowel movement.
Buy Loperamide Online. Loperamide binds to the opiate receptor in the intestinal wall and inhibits the release of acetylcholine and prostaglandins, resulting in reduced peristalsis and increased intestinal transit time.The effectiveness of loperamide 4, 8, and 12 mg in reducing symptoms of lactose intolerance has been investigated in an open study in 19 subjects [The antisecretory agent bismuth subsalicylate (Pepto-Bismol) taken as a liquid (1 ounce every 30 minutes until eight doses have been taken) works more slowly than antimotility agents.
In the event of overdosage, patients should be monitored for signs of central nervous system (CNS) depression for at least 24 hours. In addition, children may be more sensitive to the CNS effect of loperamide. Loperamide is a very effective anti-diarrhea medication. Naunyn Schmiedebergs Arch Pharmacol.
1989 Feb;8(2):252-8. doi: 10.1097/00005176-198902000-00021.Digestion. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B9780444537171009926URL: https://www.sciencedirect.com/science/article/pii/S0378608018300321URL: https://www.sciencedirect.com/science/article/pii/B9780444537171003139URL: https://www.sciencedirect.com/science/article/pii/S0378608017300247URL: https://www.sciencedirect.com/science/article/pii/S0378608017300016URL: https://www.sciencedirect.com/science/article/pii/B9781437701265000653URL: https://www.sciencedirect.com/science/article/pii/B0123868602005293URL: https://www.sciencedirect.com/science/article/pii/B978032339307200028XURL: https://www.sciencedirect.com/science/article/pii/B9780323063975000629Veterinary Toxicology for Australia and New Zealand, 2017A Worldwide Yearly Survey of New Data in Adverse Drug ReactionsA Worldwide Yearly Survey of New Data in Adverse Drug ReactionsA 45-year-old male with fatigue and loss of libido and history of ulcerative colitis was managing his symptoms with A Worldwide Yearly Survey of New Data in Adverse Drug ReactionsPharmacology and Therapeutics for Dentistry (Seventh Edition)Functional Gastrointestinal Disorders and Irritable Bowel SyndromeScienceDirect ® is a registered trademark of Elsevier B.V. Loperamide is a safe drug when used as directed.
1981 … An adult should not exceed a total of 8 mg in a 24-hour period unless directed by a physician.
Other agents such as kaolin-pectin and probiotics have been found ineffective in clinical trials.Loperamide is indicated for the symptomatic relief of acute nonspecific diarrhea and should not be used if diarrhea is accompanied by high fever (greater than 101 °F), or if blood is present in the stool, suggesting an infectious etiology.