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Key facts. Find patient medical information for Uroxatral Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. d: Capsule may be opened and … The following information includes only the average doses of this medicine. The patient should be carefully monitored, since recurrences of NMS have been reported.Prochlorperazine may impair mental and/or physical abilities, especially during the first few days of therapy. However, the dose is usually not more than 20 mg per day or longer than 12 weeks. Keep patient under observation and maintain an open airway, since involvement of the extrapyramidal mechanism may produce dysphagia and respiratory difficulty in severe overdosage. If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. Dosage of drugs is not considered in the study. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Prochlorperazine: (Minor) Use caution when administering alfuzosin with prochlorperazine due to the potential for QT prolongation.
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Do not use in children for conditions for which dosage has not been established.Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of neuroleptic drugs administered to the patient increase. Other drugs that have the same active ingredients (e.g. The dose of this medicine will be different for different patients. doses; increased appetite; increased weight; a systemic lupus erythematosus-like syndrome; pigmentary retinopathy; with prolonged administration of substantial doses, skin pigmentation, epithelial keratopathy, and lenticular and corneal deposits.EKG changes - particularly nonspecific, usually reversible Q and T wave distortions—have been observed in some patients receiving phenothiazine tranquilizers.Although phenothiazines cause neither psychic nor physical dependence, sudden discontinuance in long-term psychiatric patients may cause temporary symptoms, e.g., nausea and vomiting, dizziness, tremulousness.Note: There have been occasional reports of sudden death in patients receiving phenothiazines. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.If you miss a dose of this medicine, take it as soon as possible. If hypotension occurs after parenteral or oral dosing, place patient in head-low position with legs raised. Other pressor agents, including epinephrine, should not be used because they may cause a paradoxical further lowering of blood pressure.Aspiration of vomitus has occurred in a few post-surgical patients who have received prochlorperazine as an antiemetic. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.) c: Antacids and/or milk may prematurely dissolve the coating of the tablet. ; It's usual to take a dose two or three times a day - always follow your doctor's instructions. Prochlorperazine Suppositories, USP, a phenothiazine derivative is designated chemically as 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine with the following structural formula:Prochlorperazine is a propylpiperazine derivative of phenothiazine. If fever with grippe-like symptoms occurs, appropriate liver studies should be conducted.
Neuroleptic treatment itself, however, may suppress (or partially suppress) the signs and symptoms of the syndrome and thereby may possibly mask the underlying disease process.The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown.Given these considerations, neuroleptics should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. (Or, injectable diphenhydramine may be useful.) Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever, and autonomic reactions such as hypotension, dry mouth and ileus.TREATMENT–It is important to determine other medications taken by the patient since multiple dose therapy is common in overdosage situations.
Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology.The management of NMS should include 1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and medical monitoring, and 3) treatment of any concomitant serious medical problems for which specific treatments are available. This dosage is one 10 mg tablet of alfuzosin taken once a day after a meal.