Children younger than 2 years and patients with hereditary mitochondrial disease are at a considerably increased risk of developing fatal hepatotoxicity. Other side effects include: dyspnea, pharyngitis, tinnitus, abnormality in thinking, amnesia, ataxia, bronchitis, constipation, depression, fever, nystagmus disorder, peripheral edema, weight gain, and weight loss. Cerner Multum, Inc. "Australian Product Information." Limited data suggests valproate exposure in utero may increase risk of developing symptoms of attention deficit/hyperactivity disorder (ADHD).Contraindicated in women of child-bearing potential unless they are using effective contraceptionNo definitive adverse reactions have been reported in breastfed infants. "Product Information. Sedative effects occur most often in patients receiving combination therapy.Post marketing reports: Irregular menses, secondary amenorrhea, azoospermia, aspermia, decreased sperm count, decreased spermatozoa motility, male infertility, and abnormal spermatozoa morphology, urinary tract infection1. 5.
O 03. There are no data on the effects of this drug on milk production or excretion.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not start or stop taking the medicine during pregnancy without your doctor's advice. Nausea (31%)Headache (<31%)Increased bleeding time (26-30%)Thrombocytopenia (26-30%)Tremor (25%)Alopecia (<24%)Asthenia (16-20%)Infection (16-20%)Somnolence (16-20%)Amblyopia (11-15%)Diarrhea (11-15%)Diplopia (11-15%)Dizziness (11-15%)Dyspepsia (11-15%)Nystagmus (11-15%)Tinnitus (11-15%)Vomiting (11-15%) Depacon (valproic acid)." Increased rates of fetal structural abnormalities, intrauterine growth retardation, and embryo-fetal death have occurred with valproate administration to pregnant animals at clinically relevant doses. Abbott Pharmaceutical, Abbott Park, IL.
Tell your doctor if you start or stop using hormonal contraception that contains estrogen (birth control pills, injections, implants, skin patches, and vaginal rings). "Product Information. For these patients under 2 years, Along with its needed effects, valproic acid may cause some unwanted effects. Epidemiologic studies in children exposed in utero show that up to 40% experience delays in early development such as talking and walking later, lower intellectual abilities, poor language skills (speaking and understanding) and memory problems.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of valproic acid may occur that usually Check with your health care professional if any of the following side effects The most commonly reported side effects at the start of therapy include nausea, vomiting, and indigestion; these effects are usually transient.
Depakene (valproic acid)." Theoretically, breastfed infants are at risk for valproate-induced hepatotoxicity. Available for Android and iOS devices. Intelligence quotient (IQ) measured in children at 6 years was on average 7 to 10 points lower in children exposed to this drug in utero than those children exposed to other AEDs. "Product Information. West-Ward Pharmaceutical Corporation, Eatontown, NJ. There have been reports of hepatic failure and clotting abnormalities in offspring of women who used valproate during pregnancy.
US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Polytherapy with antiepileptic drugs (AEDs) has been associated with an increased frequency of congenital malformations compared with AED monotherapy. Failure of other Hepatotoxicity (some cases fatal), usually occurring during the first 6 months of treatment, has been reported in patients receiving valproate and its derivatives. Valproate Sodium (valproic acid)." We comply with the HONcode standard for trustworthy health information - Thrombocytopenia was reported in a 2.5-month old breastfed infant, but causality was not established, and other experts believe this was more likely caused by idiopathic thrombocytopenic purpura following a viral infection.
An observational study has suggested that exposure to valproate during pregnancy increases the risk of autism spectrum disorders. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Children younger than 2 years and patients with hereditary mitochondrial disease are at a considerably increased risk of developing fatal hepatotoxicity.