If you don't remember until the next day, call your doctor for instructions. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. These include incorrect usage, interactions with certain drugs, supplements or foods, changes in diets, and illnesses.If your doctor prescribes warfarin for you, make sure you understand what the potential side effects are and how to help prevent them.The main risk is bleeding. Warfarin treatment is a careful balance, and certain factors can tip the balance, increasing the risk of bleeding. For example, you might have trouble stopping the bleeding from a cut on your hand, or you have a nosebleed. But it's also important to remember that warfarin can result in serious side effects.The same action of warfarin that prevents blood clotting can result in bleeding. 6,13; Fluoroquinolones may increase INR by inhibiting warfarin metabolism, displacing warfarin from protein-binding sites, or disturbing intestinal flora that synthesizes vitamin K. 7,13 If you take warfarin, it's important to have a consistent amount of vitamin K in your diet. Antibiotics in the same class have similar effects on INR: Cephalosporins may increase INR by inhibiting production of vitamin K-dependent clotting factors. More than 120 drugs and foods that can interact with warfarin have been identified.Common drugs that can interact with warfarin include:Common supplements that can interact with warfarin include:Common foods and drinks that might interact with warfarin include:It's important to understand the role of vitamin K in warfarin treatment and a healthy diet. Documentation: interaction is suspected, probable or established 1 "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.© 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission.
Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. This tool may not cover all possible drug interactions. This complication occurs within a few days of starting warfarin treatment. Clinical Drug Interactions Source: Medscape from WebMDDisclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. A-Cillin Oral, Amoxil Oral, Colmox Oral, DisperMox Oral, Entamox Oral, Larotid Oral, Moxatag Oral, Mox-I 250 Oral, Moxilin Oral, Polymox Oral, Senox Oral, Sumox Oral, Trimox 125 Oral, Trimox 250 Oral, Trimox Oral, Wellamox Oral, Wymox Oral
More-serious bleeding may be inside the body (internal).Seek immediate help if you have any of the following:Rarely, warfarin can cause the death of skin tissue (necrosis). Never take a double dose.If you follow your doctor's dosing instructions and tell all your health care providers that you take warfarin, you'll be at a much lower risk of dangerous interactions and side effects. Amoxicillin may increase the effect of the blood thinner.Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment.
Drug Interaction Classification Systems: Significance Rating (A) Criteria Management Rating (B) Criteria: 0: Not listed 0: Not listed: 1: Severity - Major: The effects are potentially life-threatening or capable of causing permanent damage. Generic Brand Severity Effect on INR Notes. Seek immediate medical care if you notice any sores, changes in skin color or temperature, or severe pain on your skin.Talk to your doctor about these less serious side effects:Some studies suggest that the risk of bleeding is generally higher in the first three months of warfarin treatment. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations.Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Although commonly used to treat blood clots, warfarin (Coumadin, Jantoven) can have dangerous side effects and put you at risk of heavy bleeding. If your doctor isn't available, skip the missed dose and resume your normal dosing schedule.
Talk to your doctor, nurse or pharmacist if you have any concerns about warfarin.Mayo Clinic does not endorse companies or products.
Warfarin and Antibiotic Interactions.