Labrie V, Roder JC. Berardelli A, Currà A, Fabbrini G, Gilio F, Manfredi M. Pathophysiology of tics and Tourette syndrome. Metabolite changes resulting from treatment in children with ADHD: a 1H-MRS study.
Orhan G, Yapici N, Yuksel M, et al.
Márquez L, Camarena B, Hernández S, Lóyzaga C, Vargas L, Nicolini H. Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder. The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia. D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder. Clements JD, Westbrook GL.
Arnold PD, Macmaster FP, Richter MA, et al. Attention deficit and hyperactivity disorder scores are elevated and respond to N-acetylcysteine treatment in patients with systemic lupus erythematosus. Of the 13 patients, seven out of 13 (54%) reported a >35% reduction in the Y-BOCS severity score.
3 weeks ago, he decided he does not want to take any medication, needless to say I am sad, for I feel that he will go back to struggling with school work and following rules and back to his oppositional attitude.
Pasquini M, Berardelli I, Biondi M. Amantadine augmentation for refractory obsessive-compulsive disorder: a case report. Züchner S, Wendland JR, Ashley-Koch AE, et al.
Berman RM, Cappiello A, Anand A, et al. Donfrancesco R, Calderoni D, Vitiello B. Open-label amantadine in children with attention-deficit/hyperactivity disorder. Topiramate in the treatment of trichotillomania: an open-label pilot study.
A transgenic model of comorbid Tourette’s syndrome and obsessive-compulsive disorder circuitry. Lamotrigine for attention deficit-hyperactivity disorder comorbid with mood disorders: a case series.
Amantadine and rimantadine for influenza A in children and the elderly. However, clinician-rated improvements in behavioral ratings following treatment with amantadine suggest that further studies with this or other drugs acting on the glutamatergic system are warranted.
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Panza KE, Pittenger C, Bloch MH. Nordstrom EJ, Burton FH. Rampello L, Alvano A, Battaglia G, Bruno V, Raffaele R, Nicoletti F. Tic disorders: from pathophysiology to treatment.
2012).The CPRS–R:L is an 80 item rating scale designed to evaluate problem behaviors, ADHD, and comorbid disorders, based on Diagnostic and Statistical Manual of Mental Disorders, 4th ed.
Clinical trials of glutamate-modulating drugs in TTM and ExDA 12-week, double-blind, placebo-controlled trial of NAC 1.2–2.4 g/day in 50 adults with TTM showed a greater reduction in hair-pulling behaviors in the active drug arm.The use of NAC in ExD is highlighted by a case report of five patients with TTM or ExD who were given NAC for symptom management. Underhill SM, Wheeler DS, Li M, Watts SD, Ingram SL, Amara SG.
Sattler R, Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death.
Hertzberg MA, Butterfield MI, Feldman ME, et al.
Ruscio AM, Stein DJ, Chiu WT, Kessler RC. Clinical and sensorimotor gating effects of ketamine in normals. Krystal JH, Karper LP, Seibyl JP, et al. Amyotrophic lateral sclerosis: an update for 2013 clinical features, pathophysiology, management and therapeutic trials. Attention deficit induced by blockade of N-methyl D-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3. He started this and within weeks was doing much better. Coric V, Taskiran S, Pittenger C, et al.
Systematic review of lamotrigine augmentation of treatment resistant unipolar depression (TRD). Started back and 6 months later is doing REMARKABLY well, I can’t tell you how much of a positive difference this has made.”
Relationship between Glutamate Dysfunction and Symptoms and Cognitive Function in Psychosis.
Role of dopamine receptors in ADHD: a systematic meta-analysis. So far in school things are just okay. After 2 weeks on it we saw positive changes in his mood and 3 months dramatic changes that even the teacher commented what an amazing positive change.
There are indications of increased familiality in TTMAnimal models of OCD-RD have sought to simulate repetitive behaviors that include animal self-grooming motor sequences.
Peeters M, Maloteaux JM, Hermans E. Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum. Bowden CL, Calabrese JR, Sachs G, et al; Lamictal 606 Study Group.
Soltan-Sharifi MS, Mojtahedzadeh M, Najafi A, et al. Arnold LM, Auchenbach MB, McElroy SL.
Amantadine (Symmetrel ®) No: Placebo-controlled and open-label studies showed efficacy: Benzphetamine (Didrex ®) Yes: Randomized …
Grant JE, Odlaug BL, Hampshire A, Schreiber LR, Chamberlain SR. White matter abnormalities in skin picking disorder: a diffusion tensor imaging study.
A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Everyone around me said the meds made a huge difference, though.
No direct trials of ketamine in TS are available; therefore, data on the effect of ketamine on PPI are reviewed. Wu J, Xiao H, Sun H, Zou L, Zhu LQ.