Atenolol discussions on Drug Talk on HealthBoards.com. The maximum early effect on exercise tolerance occurs with doses of 50 to 100 mg, but at these doses the effect at 24 hours is attenuated, averaging about 50% to 75% of that observed with once a day oral doses of 200 mg.In patients with definite or suspected acute myocardial infarction, treatment with atenolol I.V. Monitor blood pressure continuously.Based on the severity of symptoms, management may require intensive support care and facilities for applying cardiac and respiratory support.The initial dose of atenolol is 50 mg given as one tablet a day either alone or added to diuretic therapy. Data from several studies, i.e., TIMI-II, ISIS-2, currently do not suggest any clinical interaction between aspirin and beta-blockers in the acute myocardial infarction setting.While taking beta-blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. For irregular heartbeats (arrhythmia) - the usual dose is 50mg to 100mg taken once a day. No studies have been performed on the use of atenolol in the first trimester and the possibility of fetal injury cannot be excluded. Dose Adjustments. 2) Atenolol; 50 -100 mg. 3) Norvasc; 5-10 mg. Atenolol is also compatible with methyldopa, hydralazine, and prazosin, each combination resulting in a larger fall in blood pressure than with the single agents.
Patients with pre-existing conduction abnormalities or left ventricular dysfunction are particularly susceptible (see It is not advisable to withdraw beta-adrenoreceptor blocking drugs prior to surgery in the majority of patients. Disopyramide has been associated with severe bradycardia, asystole and heart failure when administered with beta-blockers.Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers.Beta-blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. Atenolol is devoid of membrane stabilizing activity, and increasing the dose well beyond that producing beta-blockade does not further depress myocardial contractility. Since Atenolol is excreted via the kidneys, the dosage should be adjusted in cases of severe impairment of renal function. Several possible mechanisms have been proposed and include: (1) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output, (2) a central effect leading to reduced sympathetic outflow to the periphery, and (3) suppression of renin activity. As with other beta-blockers, when discontinuation of atenolol is planned, the patients should be carefully observed and advised to limit physical activity to a minimum. If there is no response to vagal blockade, give isoproterenol cautiously. Atenolol excretion would be expected to decrease with advancing age.No significant accumulation of atenolol occurs until creatinine clearance falls below 35 mL/min/1.73 mThe following maximum oral dosages are recommended for elderly, renally-impaired patients and for patients with renal impairment due to other causes:Some renally-impaired or elderly patients being treated for hypertension may require a lower starting dose of atenolol: 25 mg given as one tablet a day. In refractory cases, a transvenous cardiac pacemaker may be indicated.HEART BLOCK (SECOND OR THIRD DEGREE): Isoproterenol or transvenous cardiac pacemaker.CARDIAC FAILURE: Digitalize the patient and administer a diuretic. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37°C and a log partition coefficient (octanol/water) of 0.23. Beta-blockers may mask tachycardia occurring with hypoglycemia, but other manifestations such as dizziness and sweating may not be significantly affected. The study is created by eHealthMe based on reports of 1,210 people who take Benicar and Atenolol from the Food and Drug Administration (FDA), and is updated regularly. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. ... Benicar Oral. The mechanisms of the antihypertensive effects of beta-blocking agents have not been established. Atenolol may aggravate peripheral arterial circulatory disorders.The drug should be used with caution in patients with impaired renal function (see Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. No significant accumulation of Atenolol occurs in patients who have a creatinine clearance greater than 35 ml/min/1.73 m 2 (normal range is 100–150 ml/min/1.73 m 2 ).
Several studies have demonstrated a moderate (approximately 10%) increase in stroke volume at rest and during exercise.In controlled clinical trials, atenolol, given as a single daily oral dose, was an effective antihypertensive agent providing 24-hour reduction of blood pressure. The reported frequency of elicited adverse effects was higher for both atenolol and placebo-treated patients than when these reactions were volunteered. Administration of atenolol, starting in the second trimester of pregnancy, has been associated with the birth of infants that are small for gestational age.