There was a significant decrease in the number of voidings during the 6-h period after intranasal intake of desmopressin. 68382-384-01 License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Copy the URL below and paste it into your RSS Reader application.DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. The drug should be used with caution in patients with coronary artery insufficiency and/or hypertensive cardiovascular disease.Stimate Nasal Spray should be used with caution in patients with conditions associated with fluid and electrolyte imbalance, such as cystic fibrosis, heart failure and renal disorders because these patients are prone to hyponatremia.There have been rare reports of thrombotic events (thrombosis, acute cerebrovascular thrombosis, acute myocardial infarction) following desmopressin acetate injection in patients predisposed to thrombus formation.
A pharmacokinetic study was conducted in subjects with normal renal function and patients with mild, moderate, and severe renal impairment (n=24, 6 subjects each group) with a single 2 mcg dose of desmopressin acetate injection (this results in approximately 20 times the exposure of 10 mcg of desmopressin acetate nasal solution (nasal spray)). Stimate® Nasal Spray's compression pump delivers 0.1 mL (150 mcg) of solution per spray. In patients with von Willebrand's disease, levels of Factor VIII coagulant activity and von Willebrand factor antigen remained greater than 30 U/dL for 8 hours after a 300 mcg dose of Stimate Nasal Spray. This will help make sure that you receive 25 sprays with each bottle of Stimate Nasal Spray. Desmopressin acetate at up to 10 mcg/kg/day was given to pregnant rabbits by subcutaneous injection from gestation day 6 to 18 during fetal organogenesis without teratogenic effects. For those patients not responding in 100% of bleeding occasions, 78% (64 of 82) of bleeding episodes were effectively controlled with Stimate Nasal Spray.Patients may respond in a variable fashion depending on the type of molecular defect they have. However, no causal connection between these events and desmopressin acetate has been established. Therefore, in elderly patients fluid intake should be adjusted downward in an effort to decrease the potential occurrence of water intoxication and hyponatremia.
If you would like more information about Stimate Nasal Spray, talk with your healthcare provider. Therefore, fluid restriction is recommended and should be discussed with the patient and/or guardian. Intranasal desmopressin is an efficient and well-tolerated treatment of voiding problems in patients with MS during daily activities. A 15-year, Swedish epidemiologic study of the use of desmopressin acetate in pregnant women with diabetes insipidus found the rate of birth defects to be no greater than that in the general population. Factor VIII coagulant activity should be determined before giving Stimate Nasal Spray for hemostasis.
Fluid restriction should be observed, and fluid intake should be limited to a minimum, from 1 hour before desmopressin administration, until at least 24 hours after administration. Visit cvs.com … DDAVP NASAL SPRAY prescription and dosage sizes information for physicians and healthcare professionals.