Please enable it to take advantage of the complete set of features! d'Albasio G(1), Paoluzi P, Campieri M, Bianchi Porro G, Pera A, Prantera C, Sturniolo GC, Miglioli M. Author information: (1)Unità Operativa di Gastroenterologia, Ospedale Careggi, Firenze, Italy. Mesalazine; 5-Aminosalicylic acid: Französisch: Acide 5-aminosalicylique; Mésalazine; Mésalamine: Italienisch: Mesalazina CAS-Nummern: Mesalazin = 89-57-6 PubChem Eigenschaften 5-Aminosalicylsäure (Mesalazin, Mesalamin) hat den chemischen Namen 5-Amino-2-hydroxybenzoesäure und die Summenformel lautet C 7 H 7 NO 3. Epidemiological observations indicate that mesalazine can be also chemopreventive for IBD-associated CRC [4, 17, 18], even though one study has documented no benefit . A series of epidemiological, experimental and preliminary clinical trials strongly suggest that mesalazine or 5‐aminosalicyclic acid (5‐ASA) may have antineoplastic and potentially prophylactic chemopreventive properties. Putative implications in colonic cancerDecrease of oxidative DNA damage in human colonic mucosa with ulcerative colitis after the medical therapyFabrication of an electrochemical mesalazine sensor based on ZIF-67, Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases, A hydroxyethyl derivative of chrysin exhibits anti-inflammatory activity in dendritic cells and protective effects against dextran sodium salt-induced colitis in mice, Nijkamp and Parnham's Principles of Immunopharmacology, miR-206 as a Biomarker for Response to Mesalamine Treatment in Ulcerative Colitis, Immunological pathogenesis of inflammatory bowel disease, Effects of Mesalamine Treatment on Gut Barrier Integrity After Burn Injury, Electrochemical sensing of mesalazine and its N-acetylated metabolite in biological samples using functionalized carbon nanotubes, Methicillin-resistant Staphylococcus aureus buckle infection complicated by endophthalmitis and presumed choroidal abscess in a patient with ulcerative colitis, Colon Cancer Screening and Surveillance in Inflammatory Bowel Disease, Targeting eicosanoid pathways in the development of novel anti-influenza drugs, Chemoprevention of Colorectal Cancer in Inflammatory Bowel Disease, Colon cancer surveillance in inflammatory bowel disease patients: current and emerging practices, Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) new complexes of 5-aminosalicylic acid: Spectroscopic, thermal characterization and biological activity studies, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Managing Risks of Neoplasia in Inflammatory Bowel Disease, The Role of Chemoprevention of Colorectal Cancer with 5-Aminosalicylates in Ulcerative Colitis, Mesalazine as a new therapeutic option for chronic idiopathic urticaria, Baicalin Down‐regulates the Expression of Macrophage Migration Inhibitory Factor (MIF) Effectively for Rats with Ulcerative Colitis, The actin-bundling protein Fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair, Chemoprevention of colorectal cancer in inflammatory bowel disease, Best Practice & Research Clinical Gastroenterology, HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death, Immunohistochemical expression of CDX2, β‐catenin, and TP53 in inflammatory bowel disease‐associated colorectal cancer, Risk Factors for Neoplasia in Inflammatory Bowel Disease Patients With Pancolitis, Chemoprophylaxis in colorectal cancer: current concepts and a practical algorithm for use, AGA Technical Review on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease, Mesalazine inhibits the β‐catenin signalling pathway acting through the upregulation of μ‐protocadherin gene in colo‐rectal cancer cells, Combined treatment of Caco-2 cells with butyrate and mesalazine inhibits cell proliferation and reduces Survivin protein level, Colon cancer in inflammatory bowel disease: recent trends, questions and answers, Mesalamine Suppresses the Expression of TC22, a Novel Tropomyosin Isoform Associated with Colonic Neoplasia, MMX mesalamine: a novel high-dose, once-daily 5-aminosalicylate formulation for the treatment of ulcerative colitis, Can we prevent inflammatory bowel disease-related colorectal cancer with 5-aminosalicylic acid, azathioprine, or 6-mercaptopurine? Moreover studies conducted in experimental models of carcinogenesis have shown that the drug has many targets in cancer cells and modulates multiple biological pathways that sustain CRC [ 20 ]. 2015 Sep;53(9):1091-8. doi: 10.1055/s-0041-103377.