The mortality rate for the three VaD studies combined in the donepezil hydrochloride group (1.7%) was numerically higher than in the placebo group (1.1%), however, this difference was not statistically significant. By continuing to browse the site you are agreeing to our policy on the use of cookies. Dose-related signs of cholinergic stimulation were observed in animals and included reduced spontaneous movement, prone position, staggering gait, lacrimation, clonic convulsions, depressed respiration, salivation, miosis, fasciculation and lower body surface temperature.Overdosage with cholinesterase inhibitors can result in cholinergic crisis characterised by severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Your reactions could be impaired.Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as Other drugs may affect donepezil, including prescription and over-the-counter medicines, Your pharmacist can provide more information about donepezil.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Tertiary anticholinergics such as atropine may be used as an antidote for ARICEPT EVESS overdosage. Treatment should be stopped if … This site uses cookies. It is not known whether donepezil hydrochloride is excreted in human breast milk and there are no studies in lactating women.
Donepezil hydrochloride has the potential to interfere with medications having anticholinergic activity. Therefore these and other CYP3A4 inhibitors, such as itraconazole and erythromycin, and CYP2D6 inhibitors, such as fluoxetine could inhibit the metabolism of donepezil. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. Use, however, has not been shown to change the progression of the disease. ©2020 WebMD, Inc. All rights reserved.What are the possible side effects of donepezil (Aricept, Aricept ODT)?What is the most important information I should know about donepezil (Aricept, Aricept ODT)?What should I discuss with my healthcare provider before taking donepezil (Aricept, Aricept ODT)?How should I take donepezil (Aricept, Aricept ODT)?What happens if I miss a dose (Aricept, Aricept ODT)?What should I avoid while taking donepezil (Aricept, Aricept ODT)?What other drugs will affect donepezil (Aricept, Aricept ODT)?Where can I get more information (Aricept, Aricept ODT)? About donepezil; Key facts; Who can and cannot take donepezil ; How and when to take it; Side effects; How to cope with side effects; Cautions with other medicines; Common questions; 1. DSM IV, ICD 10). OTC products should only be used to prevent or treat the symptoms of mild, occasional, self-treatable episodes of nausea and vomiting. The metabolism of donepezil hydrochloride is not affected by concurrent administration of digoxin or cimetidine. However, seizure activity may also be a manifestation of Alzheimer's disease.Cholinomimetics may have the potential to exacerbate or induce extrapyramidal symptoms.NMS, a potentially life-threatening condition characterised by hyperthermia, muscle rigidity, autonomic instability, altered consciousness and elevated serum creatine phosphokinase levels, has been reported to occur very rarely in association with donepezil, particularly in patients also receiving concomitant antipsychotics.
If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.As in any case of overdose, general supportive measures should be utilised.