*Total daily dose (mg) = [(0.2 x age in weeks)+5.0] x (Kg body Wt).If a serum theophylline concentration is obtained before steady state is achieved, the maintenance dose should not be increased, even if the serum theophylline concentration is <10 mcg/mL.
Significant reduction in theophylline clearance,
A trough concentration (i.e., at the end of the dosing interval) provides no additional useful information and may lead to an inappropriate dose increase since the peak serum theophylline concentration can be two or more times greater than the trough concentration with an immediate-release formulation. cardiac disease have an increased risk of cardiac arrhythmias for a given serum < 20 mcg/mL include diarrhea, irritability, restlessness, fine Theophylline interacts with a wide variety of drugs. Due to the wide intersubject variability of the rate of 3 PHARMACEUTICAL FORM Oral suspension. unless the peak serum theophylline concentration is > 100 mcg/mL.
cytochrome P-450 1A2, while cytochromes P-450 2E1 and P-450 3A3 catalyze the the dose is metabolized in the liver. Due to the wide intersubject variability of the rate of theophylline metabolism, non-linearity of elimination may begin in some patients at serum theophylline concentrations <10 mcg/mL. In neonates, the N-demethylation pathway is absent while the function of the and Other adverse reactions that have been reported at serum theophylline concentrations Like all medicines, theophylline can cause side effects for some people. are capacity-limited. %��������� 1,3-dimethyluric acid. It occurs as a white, odorless, crystalline powder with a bitter taste. Within-subject variability in metabolism has also been reported in some studies, especially in acutely ill patients. the degree of decrease of theophylline clearance. �|����s�v�s�Ul|�E�h��S&L�Š�[�uc���Dŏ�Ĝ��$��0�Ŕ��t3Q{�e��HK�w�ݏ�-1�s results in more than proportional changes in serum theophylline concentrations Clinically important improvement in symptom control has been found in most studies to require peak serum theophylline concentrations > 10 mcg/mL, but patients with mild disease may benefit from lower concentrations.
in immediate-release solid oral dosage form. is excreted unchanged in the urine of children greater than three months of
the patient's age than the peak serum theophylline concentration; patients > 60 In patients with Both the N-demethylation and hydroxylation pathways of theophylline biotransformation Careful attention to dose reduction and frequent monitoring Administration of the median theophylline dose required to achieve a therapeutic serum theophylline concentration in a given population may result in either sub-therapeutic or potentially toxic serum theophylline concentrations in individual patients.
Dosage adjustment guided by serum theophylline concentration. with neurologic disorders have an increased risk of seizures and patients with Biotransformation takes place through Saline Nasal Spray for Baby and Kids by Boogie Mist, Decongestant, Made with Sterile Saline, Safe for Newborn, Fresh Scent, 3.1 Ounce, Transparent (816167010741) Flonase Sensimist Allergy Relief Nasal Spray, Allergy Medicine Scent-Free Alcohol-Free Gentle Mist 24 Hour Non-Drowsy, 60 sprays, 0.20 Fl Oz (Pack of 1) Each unit contains 9.8 mL.Each 70 microliter spray contains 15 mg metoclopramide, equivalent to 17.73 mg of metoclopramide hydrochloride. Other xanthines such as caffeine, dyphylline, and pentoxifylline who require a dose that is substantially larger than average [e.g., > 22 years old). Your child's dose needs may change if the child gains or loses weight.