However, our conclusions alone cannot be taken to In summary, while ARBs are slightly better tolerated than ACE inhibitors, there is a higher quality of Our analyses found no evidence of a difference in total Angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARBs) are widely prescribed for primary To compare the effects of ACE inhibitors and ARBs on total We searched the Cochrane Hypertension Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), We used standard methodological procedures expected by The Cochrane Collaboration.Nine studies with 11,007 participants were included.
(Strength of Recommendation [SOR]: A, based on a meta-analysis.) Of the included studies, five reported Li ECK, Heran BS, Wright JM. 2013 Jun;11(6):705-17. doi: 10.1586/erc.13.42.Trietley GS, Wilson SA, Chaudhri P, Payette N, Higbea A, Nashelsky J.Wu HY, Huang JW, Lin HJ, Liao WC, Peng YS, Hung KY, Wu KD, Tu YK, Chien KL.BMJ. Name must be less than 100 characters ACE inhibitors cause your blood vessels to relax and your blood pressure to decrease. Cochrane Database Syst Rev. This article provides some information about them and also a comparison between the two, in terms of their nature, mode of action, and the preferred drug for an affected person. In the propensity score–adjusted REACH (Reduction of Atherothrombosis for Continued Health) cohort of 40,625 patients (91% with hypertension) (ACE inhibitors 67.9% and ARBs 32.1%), the incidence of the primary outcome, a composite of CV mortality, nonfatal myocardial infarction (MI), nonfatal stroke, or hospitalization for CV reasons, was lower in patients taking ARBs compared with … Clipboard, Search History, and several other advanced features are temporarily unavailable. Despite treating many similar conditions, beta-blockers work differently than ACE inhibitors, and target beta-1 receptors that sit on heart muscle cells to reduce heart rate and blood pressure. ACE Inhibitors vs ARBs for Primary Hypertension Am Fam Physician. The primary objective is to quantify the dose-related systolic (SBP) and/or diastolic blood pressure (DBP) lowering efficacy of renin inhibitors vs placebo in the treatment of primary hypertension. doi: 10.1136/bmj.f6008.Kim J, Choi SM, Lee J, Park YS, Lee CH, Yim JJ, Yoo CG, Kim YW, Han SK, Lee SM.Korean J Crit Care Med. Beta Blockers. No.
Cochrane Database of Systematic Reviews 2014, Issue 8. Do ACE inhibitors and ARBs offer better protection for those with renal nephropathy over other antihypertensives? 2017 May;32(2):154-163. doi: 10.4266/kjccm.2016.00976. 2013 Oct 24;347:f6008.
Please enable it to take advantage of the complete set of features! Take this short survey so Cochrane can better meet your needs in the future. In total, 91.8% of patients who had RAAS inhibition suspended were alive and out of hospital at 30 days compared with 95.0% of who continued with ACE inhibitors/ARBs. Unable to load your collection due to an error DOI: 10.1002/14651858.CD009096.pub2We use cookies to improve your experience on our site.
ACE inhibitors are known to reduce cardiovascular morbidity and mortality, as well as proteinuria in patients with vascular disease or diabetes, whether or not they have heart failure. doi: 10.1002/14651858.CD009096.pub2.Expert Rev Cardiovasc Ther. Or, is that unproven dogma about renin-angiotensin blockade? Art.
ACE inhibitors should be used in patients with hypertension because they reduce all-cause mortality, whereas ARBs do not. Background. Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension. American Academy of Family Physicians Epub 2017 May 31.Tabesh M, Magliano DJ, Tanamas SK, Surmont F, Bahendeka S, Chiang CE, Elgart JF, Gagliardino JJ, Kalra S, Krishnamoorthy S, Luk A, Maegawa H, Motala AA, Pirie F, Ramachandran A, Tayeb K, Vikulova O, Wong J, Shaw JE.Diabet Med. COVID-19 is an emerging, rapidly evolving situation. 2015 Apr 15;91(8):522-3. 2019 Jul;36(7):878-887. doi: 10.1111/dme.13858. American Academy of Family Physicians Unable to load your delegates due to an error 2014 Aug 22;2014(8):CD009096. This site needs JavaScript to work properly. Hypertension, or persistent high blood pressure above 140/90 mmHg, is a prevalent We found no reliable difference between ACE inhibitors and ARBs for total deaths, deaths due to heart disease, or total heart disease and stroke. ACE inhibitors and beta blockers are used in the treatment of high blood pressure. : CD009096. Hypertension, or persistent high blood pressure above 140/90 mmHg, is a prevalent risk factor that is associated with strokes and heart disease. 2 But few studies have compared the effects of ACE inhibitors and ARBs in high-risk patients without heart failure.