Die Summenformel von Aciclovir lautet C 8 H 11 N 5 O 3, die molare Masse beträgt 225,21 g/mol.
Acyclovir decreased the duration of viral excretion, new lesion formation, and duration of vesicles, and promoted healing of lesions.Sixty-two patients ages 6 months to 79 years with brain biopsy-proven herpes simplex encephalitis were randomized to receive either acyclovir (10 mg/kg every 8 hours) or vidarabine (15 mg/kg/day) for 10 days (28 were treated with acyclovir and 34 with vidarabine).
Please confirm that you would like to log out of Medscape. zovirax-acyclovir-342601 2010 The pH has been adjusted with sodium hydroxide and if necessary, hydrochloric acid to fall in the range o…
The peak and trough plasma levels during the 47 hours preceding hemodialysis were 8.5 mcg/mL and 0.7 mcg/mL, respectively.Acyclovir pharmacokinetics were determined in 16 pediatric patients with normal renal function ranging in age from 3 months to 16 years at doses of approximately 10 mg/kg and 20 mg/kg every 8 hours (Table 3). Pharmacokinetics of Acyclovir and Its Metabolites in Cerebrospinal Fluid and Systemic Circulation after Administration of High-Dose Valacyclovir in Subjects with Normal and Impaired Renal Function.
COVID-19 is an emerging, rapidly evolving situation. This has resulted in elevated BUN and serum creatinine, and subsequent renal failure. Acyclovir is an antiviral drug active against herpes viruses. Diseases & Conditions dose not due right after dialysis; PD: give 50% usual dose IV q24h; no supplement hepatic dosing [not defined] Pediatrics 1980; 65:725. 2019 May 3;14(5):e0215837. Unable to load your collection due to an error 5mg/kg/dose IV q24h. Overall mortality at 12 months for patients treated with acyclovir was 25% compared to 59% for patients treated with vidarabine. ), ondansetron, piperacillin-tazobactam, sargramostim, vinorelbineY-site (partial list): Allopurinol, ampicillin, cefazolin, cimetidine, diphenhydramine, fluconazole, heparin, linezolid, lorazepam, magnesium sulfate, potassium chloride, propofol, trimethoprim-sulfamethoxazole, vancomycinAvoid rapid infusion; infuse over 1 hr at constant rate to prevent renal damageCapsule, oral suspension, tablet: Store at room temperature of 15-25°C (59-77°F); protect from moisturePowder for injection: Store undiluted vials at 15-25°C (59-77°F); following reconstitution (final concentration 50 mg/mL), solution is stable for 12 hr at room temperatureSolution for injection: Store solution at 20-25°C (68-77°F)Reconstituted solutions: Do not refrigerate; once diluted with 0.9% NaCl or D5W, use within 24 hrAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. 10-25 mL/min.
provider for the most current information.The recipient will receive more details and instructions to access this offer.By clicking send, you acknowledge that you have permission to email the recipient with this information.The recipient will receive more details and instructions to access this offer.By clicking send, you acknowledge that you have permission to email the recipient with this information. Acyclovir is an antiviral drug active against herpes viruses. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvem92aXJheC1hY3ljbG92aXItMzQyNjAx Controlled studies in pregnant women show no evidence of fetal risk.Interferes with DNA polymerase to inhibit DNA replication via chain terminationDistributed widely (brain, kidney, lungs, liver, spleen, muscle, uterus, vagina, cerebrospinal fluid [CSF])Half-life: 4 hr (Neonates); 2-3 hr (children 1-12 years); 3 hr (adults)Y-site: Amifostine, amsacrine, aztreonam, cefepime, dobutamine, dopamine, fludarabine, foscarnet, gemcitabine, idarubicin, levofloxacin, morphine sulfate (? Other reported clinical experience has identified differences in the severity of CNS adverse events between elderly and younger patients (see The adverse reactions listed below have been observed in controlled and uncontrolled clinical trials in approximately 700 patients who received acyclovir at ~5 mg/kg (250 mg/mThe most frequent adverse reactions reported during administration of acyclovir were inflammation or phlebitis at the injection site in approximately 9% of the patients, and transient elevations of serum creatinine or BUN in 5% to 10% (the higher incidence occurred usually following rapid [less than 10 minutes] intravenous infusion).