They will investigate whether hydroxychloroquine and chloroquine can be used safely to prevent the spread of disease in people who have been exposed, or are at high risk of exposure, to the coronavirus. It is a white, odorless, bitter tasting, crystalline substance, freely soluble inwater.Chloroquine phosphate tablets are an antimalarial and amebicidal drug.Chemically, it is 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline phosphate (1:2) andhas the following structural formula:C18H26ClN3.2H3PO4 Molecular Weight: 515.87Each tablet contains 500 mg of Chloroquine p… Select one or more newsletters to continue. Given its multiple effects, it's not surprising that the drug also has a variety of side effects, the … The main metabolite is desethylChloroquine, which accounts for one fourth of the total material appearing in the urine; bisdesethylChloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts. Chloroquine phosphate can cause serious vision problems. Beilstein/REAXYS Number 4223142 . Available for Android and iOS devices. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B0123694000002246URL: https://www.sciencedirect.com/science/article/pii/B9780123864543007107URL: https://www.sciencedirect.com/science/article/pii/B9780080468846004218URL: https://www.sciencedirect.com/science/article/pii/B9780444521668500376URL: https://www.sciencedirect.com/science/article/pii/B9780080977744003399URL: https://www.sciencedirect.com/science/article/pii/S0165720897800384URL: https://www.sciencedirect.com/science/article/pii/B9780128008744000143URL: https://www.sciencedirect.com/science/article/pii/S0065774308610775URL: https://www.sciencedirect.com/science/article/pii/B978012409547211056XBioinorganic Fundamentals and Applications: Metals in Natural Living Systems and Metals in Toxicology and MedicineComprehensive Inorganic Chemistry II (Second Edition)Approaches to Design and Synthesis of Antiparasitic DrugsDrugs and Drug Leads Based on Natural Products for Treatment and Prophylaxis of MalariaAntimicrobial Potentiation Approaches: Targets and InhibitorsDrugs for Parasitic Infections: Advances in the Discovery of New AntimalarialsReference Module in Chemistry, Molecular Sciences and Chemical EngineeringScienceDirect ® is a registered trademark of Elsevier B.V. Synonyms of this drug are nivaquine, quingamine, delagil, resoquine, atroquine, and others.Besides metal–CQ complexes, another class of Schiff-base phenolate– or amine phenol–metal complexes with enhanced cell-membrane permeability have become favorable antimalarial candidates.The synthesis of various 4-aminoquinoline antimalarials may be achieved by nucleophilic reaction of With growing evidence that chloroquine resistance patterns are modulated Members of the quinoline family in general exert their effect during the intraerythrocytic phase of the After the emergence of parasites that are resistant to CQ, a number of structure–activity relationship studies were initiated to understand the stereoelectronic factors that are essential for the observed antiplasmodial action and those characteristics that contribute to parasitic resistance.The weak base property of CQ allows it to diffuse through plasma and vacuolar membranes. Use chloroquine phosphate exactly as directed. Information is also available online at Children are especially sensitive to an overdose, so keep the medication out of the reach of children.Keep all appointments with your doctor and the laboratory.