amoxicillin or metronidazole and e.g. Concomitant administration of rifabutin and clarithromycin resulted in an increase in rifabutin, and decrease in clarithromycin serum levels together with an increased risk of uveitis.The following drugs are known or suspected to affect circulating concentrations of clarithromycin; clarithromycin dosage adjustment or consideration of alternative treatments may be required.Strong inducers of the cytochrome P450 metabolism system such as efavirenz, nevirapine, rifampicin, rifabutin, and rifapentine may accelerate the metabolism of clarithromycin and thus lower the plasma levels of clarithromycin, while increasing those of 14-OH-clarithromycin, a metabolite that is also microbiologically active. Do not store the suspension in the syringe.Do not dispose of medications in wastewater (e.g. lung disease depend upon the type and extent of the infection, and the person's health.Mycobacterium marinum (M. marinum) is bacteria found in fresh and saltwater that can infect the skin through cuts or scrapes, causing granulomas to appear on the skin near the site of infection. clarithromycin ER 500 mg tablet,extended release 24 hr. Endocarditis (Off-label) Used off-label for bacterial endocarditis prophylaxis. Concomitant administration of clarithromycin (500 mg twice daily) and saquinavir (soft gelatin capsules, 1200 mg three times daily) to 12 healthy volunteers resulted in steady-state AUC and Cmax values of saquinavir which were 177% and 187% higher than those seen with saquinavir alone. Patients should be monitored for signs and symptoms of myopathy.Drugs that are inducers of CYP3A (e.g. The main pharmacodynamic parameters to predict macrolidenactiviteit are unconvincing established. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Renal impairment. Slightly higher incidences of abnormal values were noted for patients who received 4,000 mg daily for all parameters except White Blood Cell.Reporting suspected adverse reactions after authorisation of the medicinal product is important. An additional 10% to 15% is excreted in the urine as 14-hydroxy metabolite. If treatment with clarithromycin cannot be avoided, therapy with lovastatin or simvastatin must be suspended during the course of treatment. Because 14-OH-clarithromycin has reduced activity against Mycobacterium avium complex (MAC), overall activity against this pathogen may be altered; therefore alternatives to clarithromycin should be considered for the treatment of MAC.Concomitant administration of fluconazole 200 mg daily and clarithromycin 500 mg twice daily to 21 healthy volunteers led to increases in the mean steady-state minimum clarithromycin concentration (Cmin) and area under the curve (AUC) of 33% and 18% respectively. sore throat, muscle
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. After one to two weeks, the second stage of whooping cough begins.Legionellosis is an infection caused by the Legionella pneumophila bacterium. somnolence and confusion) with the concomitant use of clarithromycin and triazolam. Concomitant administration of oral midazolam and clarithromycin should be avoided. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Serum levels of quinidine and disopyramide should be monitored during clarithromycin therapy.There have been post marketing reports of hypoglycemia with the concomitant administration of clarithromycin and disopyramide. Dosage Modifications. It is important to take this medication exactly as prescribed by your doctor.