Colchicine Survival of All Randomized AIDS Patients Over Time in Trial 3Dose-Ranging Monotherapy Trials in Adult AIDS Patients with MACDosage-Ranging Monotherapy Trials in Pediatric AIDS Patients with MACCombination Therapy in AIDS Patients with Disseminated MACOtitis Media Trial of Clarithromycin vs. During the first four weeks of therapy, while patients were maintained on their originally assigned dose, there were 11 deaths in 255 patients taking 500 mg twice daily and 18 deaths in 214 patients taking 1000 mg twice daily.Trial 4 was a pediatric trial of 3.75 mg/kg, 7.5 mg/kg, and 15 mg/kg of Clarithromycin twice daily in patients with CDC-defined AIDS and CDTrial 5 compared the safety and efficacy of Clarithromycin in combination with ethambutol versus Clarithromycin in combination with ethambutol and clofazimine for the treatment of disseminated MAC (dMAC) infection. Survival in the two groups was similar beyond 12 weeks. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. End-of-Treatment Ulcer Healing Rates Percent of Patients Healed (n/N)Eradication of H. pylori Associated with Duodenal UlcerTable 22. Clarithromycin can increase the steady-state concentrations of drugs that are primarily depend upon CYP3A metabolism (e.g., astemidole, cisapride, pimozide, midazolam and triazolam). doi: 10.2165/00003088-199937050-00003. The decreased formation of 14-OH Clarithromycin was at least partially offset by an increase in renal clearance of Clarithromycin in the subjects with impaired hepatic function when compared to healthy subjects.The pharmacokinetics of Clarithromycin was also altered in subjects with impaired renal function Following administration of fluconazole 200 mg daily and Clarithromycin 500 mg twice daily to 21 healthy volunteers, the steady-state Clarithromycin CWhen a single dose of colchicine 0.6 mg was administered with Clarithromycin 250 mg BID for 7 days, the colchicine CFollowing administration of Clarithromycin (500 mg twice daily) with atazanavir (400 mg once daily), the Clarithromycin AUC increased 94%, the 14-OH Clarithromycin AUC decreased 70% and the atazanavir AUC increased 28%.Concomitant administration of Clarithromycin and ritonavir (n = 22) resulted in a 77% increase in Clarithromycin AUC and a 100% decrease in the AUC of 14-OH Clarithromycin.Following administration of Clarithromycin (500 mg bid) and saquinavir (soft gelatin capsules, 1200 mg tid) to 12 healthy volunteers, the steady-state saquinavir AUC and CSimultaneous administration of Clarithromycin tablets and didanosine to 12 HIV-infected adult patients resulted in no statistically significant change in didanosine pharmacokinetics.Following administration of Clarithromycin 500 mg tablets twice daily with zidovudine 100 mg every 4 hours, the steady-state zidovudine AUC decreased 12% compared to administration of zidovudine alone (n=4). A separate trial with a four-drug regimenClinical outcomes evaluated with the different dosing regimens of Clarithromycin monotherapy are shown in Table 14. Clarithromycin tablets therapy should continue if clinical response is observed. Please enable it to take advantage of the complete set of features! Clarithromycin can increase the steady-state concentrations of drugs that are primarily depend upon CYP3A metabolism (e.g., astemidole, cisapride, pimozide, midazolam and triazolam). American Society of Health-System Pharmacists 2012; Drug Information 2012. Plasma levels in rats after 150 mg/kg/day were twice the human serum levels.Testicular atrophy occurred in rats at doses 7 times, in dogs at doses 3 times, and in monkeys at doses 8 times greater than the maximum human daily dose (on a body surface area basis).Corneal opacity occurred in dogs at doses 12 times and in monkeys at doses 8 times greater than the maximum human daily dose (on a body surface area basis). On an intent-to-treat basis, the one-year cumulative incidence of MAC bacteremia was 5.0% for patients randomized to Clarithromycin and 19.4% for patients randomized to placebo. For a single 500 mg dose of Clarithromycin, food slightly delays the onset of Clarithromycin absorption, increasing the peak time from approximately 2 to 2.5 hours.