Calcium channel blockers and beta blockers are drugs that are used to treat angina, heart failure, migraines, and high-blood pressure.
1.Vinceneux P, Canal M, Domart Y, Roux A, Cascio B, Orofiamma B, Larribaud J, Flouvat B, Carbon C. Pharmacokinetic and pharmacodynamic interactions between nifedipine and propranolol or betaxolol. The information It appears you don't have enough CME Hours to take this Post-Test. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Adalat rated 7.4/10 vs Nifedipine rated 5.5/10 in overall patient satisfaction. Feel free to buy additional CME hours or upgrade your current CME subscription planOne of the benefits of an ObGFirst subscription is the ability to earn CME/CE credits from the ObG entries you read. To compare the efficacy of intravenous labetalol with oral nifedipine in the treatment of severe hypertension in pregnancy with blood pressure ≥160/110 mm Hg.We conducted a parallel double-blinded randomized controlled trial between December 2014 to December 2016 in 120 antenatal women of gestational age >28 weeks, admitted with severe hypertension of blood pressure ≥160/110 mm Hg to maternity ward at a tertiary hospital.The labetalol group received 20 mg initially followed by escalating doses of 40 mg, 80 mg, 80 mg and 80 mg (5 doses) every 15 min to a maximum of 300 mg. Nifedipine group received 10 mg initially followed by repeated doses of 20 mg every 15 min (total 5 doses) to a maximum of 90 mg. Vital signs were recorded every 15 min.-The time taken and the number of doses required to achieve the target blood pressure (150/100 mmHg). Nifedipine group required significantly lower doses (1.82 ± 0.83) as compared to labetalol (2.45 ± 1.32) [p = 0.002].
Nifedipine group had more urine output than labetalol group.
Siddhartha Medical College.We use cookies to help provide and enhance our service and tailor content and ads. Labetalol: (Moderate) In general, concomitant therapy of nifedipine with beta-blockers is well tolerated and can even be beneficial in some cases (i.e., inhibition of nifedipine-induced reflex tachycardia by beta-blockade).
At enrolment for this study, median diastolic BP in nifedipine group was marginally but statistically significantly higher.
That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Combining propranolol (Inderal) or pindolol (Visken) with thioridazine (Mellaril) or chlorpromazine may result in low blood pressure (hypotension) and abnormal heart rhythms because the drugs interfere with each other's elimination and result in increased levels of the drugs. nifedipine, 24 hours after control of blood pressure, no significant difference was found between group A and Group B(p=0.465 for systolic and p=0.0876 for diastolic blood pressure). Oral nifedipine and intravenous labetalol show similar efficacy in their ability to control hypertensive emergencies of pregnancy, according to new research published in BJOG: An International Journal of Obstetrics & Gynaecology.. This article discusses the uses and side effects of these medicines. Davis Company PDF Page #2 2 Implementation However, Raheem et al found no evidence of a statistically significant difference between nifedipine and labetalol. Therefore, we are not responsible for the content or availability of this site Nifedipine reduced BP more rapidly than Labetalol. The planners of this activity do not recommend the use of any agent outside of the labeled indications.The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Beta Blockers ARBs.
It's free & anonymous.. Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. The study also used lower doses of nifedipine … There was significant difference between … Please sign up or log in to your ObGFirst to access this Premium Content OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Oral Nifedipine may be a better alternative because of its ease of oral administration and a flat dosing regimen.Place of Study- Vijayawada, Andhra Pradesh, India, Institute- Govt. Negative inotropic and/or chronotropic effects …
Nifedipine was 1.8 times more likely to achieve target blood pressure (Hazard Ratio = 1.8).Both intravenous Labetalol and oral Nifedipine were effective in controlling blood pressure. Find out side effects or drug interactions of your drugs and supplements from people like you, same gender and age (0-99+), by studying 16 million patients from the FDA.