Neither autopsy nor inspection nor histological examination revealed any changes in the rabbit eyes.Do not store above 25°C. Other drugs affecting renal physiology could potentially influence the pharmacokinetics of aciclovir. When suggestions are available use up and down arrows to review and ENTER to select. contact dermatitis).Only recommended for use on cold sores on the lips and face.Aciclovir cream contains a specially formulated base and should not be diluted or used as a base for the incorporation of other medicaments.Probenecid increases the mean half-life and area under the plasma concentration curve of the systemically administered aciclovir. High levels of bacteria and other organisms in the upper genital tract have a detrimental effect on pregnancy rate after ET. Properly discard this product when it is expired or no longer needed. Continue typing to refine. The conversion of aciclovir is catalysed by viral HSV- or VZV - thymidine kinase. However the accidental, repeated overdose of oral aciclovir, over several days has resulted in gastrointestinal effects (nausea and vomiting) and neurological effects (headache and confusion).Aciclovir is dialysable.Aciclovir is a pharmacologically inactive substance. There were neither systemic nor local toxic symptom. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.Overdose is unlikely to occur, if the cream is applied locally and as indicated. Two generation studies in mice did not reveal any effect of orally administered aciclovir on fertility.There is no experience of the effect of aciclovir tablets on human female fertility. This is because it may irritate these parts of your body. This information is intended for use by health professionalsThe treatment of Herpes Simplex virus infections of the lips and face (Herpes labialis). Human thymidine kinase does not use aciclovir effectively as a substrate, hence the toxicity to mammalian host cells is low.In the infected cell, aciclovir is phosphorylated by viral thymidine kinase to aciclovir monophosphate, which is further converted by cellular enzymes to aciclovir triphosphate. Most of the clinical isolates with reduced sensitivity showed a relative lack of virus thymidine kinase. Cream: Store below 25C (77F); excursions permitted to 15C to 30C (59F to 86F) General:-In clinical trials, use of the 5% cream reduced the mean duration of recurrent herpes labialis by approximately one-half day; this product is not a cure for cold sores. The intracutaneous concentration levels are higher than the minimal inhibitory concentration (MIC) in tissue at steady state.After topical application of aciclovir, no aciclovir plasma concentrations could be determined.As the aciclovir plasma concentrations following topical application are below the limit of detection, no pharmacokinetic studies are available on topical aciclovir. You may report side effects to Health Canada at 1-866-234-2345.This medicine may be harmful if swallowed. Aciclovir triphosphate has a greater affinity for viral DNA polymerase than host cell DNA polymerase and therefore selectively interferes with the viral enzyme causing inhibition of viral DNA replication. These levels would potentially expose breast fed infants to aciclovir doses of up to 0.3mg/kg/day.Frequency: very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1,000, <1/100); rare ≥1/10,000, <1/1,000), very rare (<1/10,000).• Immediate hypersensitivity reactions including angioedema and urticaria• Transient burning or stinging following application of aciclovir cream• Contact dermatitis following application. This medication works best when the amount of drug absorbed by the To prevent washing off the medication, do not bathe, shower, or swim right after applying it.If you are using acyclovir for treatment of genital herpes, it is important to follow Tell your doctor if your condition persists or worsens after treatment is finished.This is not a complete list of possible side effects. The in vitro studies used human skin biopsates, whilst the bioassays either used human skin grafts on mice or were carried out in the human eye (3 patients).
Cold sores ( herpes ) can spread easily.
Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. It allows continued monitoring of the benefit/risk balance of the medicinal product. Acyclovir cream does not prevent the spread of herpes. Do not use this drug more often or for longer than prescribed.Use this medication regularly to get the most benefit from it.