Similar to betaxolol and atenolol, metoprolol, in low doses, selectively blocks beta1-adrenergic receptors in the heart and vascular smooth muscle. Toprol Xl is a beta-blocker used to treat high blood pressure, heart pain, abnormal rhythms of the heart. This pharmacy is duly licensed in the province of British Columbia, Canada by the College of Pharmacists of BC.
General Administration Information For storage information, see the specific product information within the How Supplied section. Concurrent use may increase metoprolol exposure.
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The use of the IBM Micromedex products is at your sole risk. METOPROLOL (me TOE proe lole) is a beta-blocker. Prescription Data for Drugs containing Toprol XL under Medicare's Part D Prescription Drug Program. Like other beta-adrenergic antagonists, metoprolol competes with adrenergic neurotransmitters (e.g., catecholamines) for binding at sympathetic receptor sites. The Program, as well as the prices and the list of covered drugs, can be modified at any time without notice.This feature requires registration. Sign up or log in to your free WellRx account to gain access to this and other tools to help make managing your medications and wellness easier.This feature requires registration. I understand I can opt out at any time, by clicking the 'unsubscribe' button found in the price drop alert emails I receive.Prescription prices may vary from pharmacy to pharmacy and are subject to change. The drug is approximately 10% to 12% bound to serum albumin. In February 2001 Toprol-XL(TM) was approved for the treatment of stable, symptomatic (NYHA Class II-III) heart failure of ischemic, hypertensive, or cardiomyopathic origin, largely based on the MERIT-HF study findings. Sign up or log in to your free WellRx account to gain access to this and other tools to help make managing your medications and wellness easier.You will be redirected to your program in 5 seconds. Beta-blockers reduce the workload on the heart and help it to beat more regularly.
To check Nimbex interaction with other drugs. Only your doctor or pharmacist can provide you with advice on what is safe and effective for you. These guidelines do, however, recommend the use of beta-blockers for the treatment of hypertension in patients with angina, prior myocardial infarction, or heart failure. It has moderate lipid solubility, lacks intrinsic sympathomimetic activity (ISA), and has weak membrane stabilizing activity (MSA). Pharmacy Manager: Sanaa Abdelati. Combinations of drugs, check of their compatibility and other information are provided for reference and cannot serve as a sufficient basis for deciding on the joint use of various drugs. Abrupt discontinuation of any beta-adrenergic-blocking agent, including metoprolol, can result in the development of myocardial ischemia, myocardial infarction, ventricular arrhythmias, or severe hypertension, particularly in patients with preexisting cardiac disease. Metoprolol crosses the blood-brain barrier, with 78% of plasma concentration distributing to cerebrospinal fluid. IBM Watson Health does not assume any responsibility or risk for your use of the IBM Micromedex products. In February 2001 Toprol-XL(TM) was approved for the treatment of stable, symptomatic (NYHA Class II-III) heart failure of ischemic, hypertensive, or cardiomyopathic origin, largely based on the MERIT-HF study findings. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy*Average and up to savings percentages are based on all discount prescriptions that were run through the WellRx program in 2019. Safety and efficacy not established. A dosage reduction for metoprolol may be needed based on response. Metoprolol has a relatively short elimination half-life compared to other cardioselective beta-blockers.
It also crosses the placenta and is concentrated in breast milk; equilibrium in the placenta is attained 4 to 5 hours after dosing. The 2007 AHA guidelines for the management of hypertension state beta-blockers should not be used as first-line therapy for the treatment of hypertension, as several comparative clinical trials have shown beta blockers to be inferior to ACE inhibitors, angiotensin-receptor blockers, or calcium channel blockers for preventing both stroke and coronary artery disease complications. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER).