Protect from freezing.This leaflet contains important information about Fluconazole (FLEW-kan-a-zol). Fluconazole causes QT prolongation via the inhibition of Rectifier Potassium Channel current (Ikr). Severe Interactions. (See The use of Fluconazole in children with cryptococcal meningitis, In a noncomparative study of children with serious systemic fungal infections, most of which were candidemia, the effectiveness of Fluconazole was similar to that reported for the treatment of candidemia in adults. No significant pharmacokinetic changes have been observed when tacrolimus is given intravenously. If you develop any side effects that concern you, call your doctor. Other side effects reported with an incidence equal to or greater than 1% included diarrhea (3%), dyspepsia (1%), dizziness (1%), and taste perversion (1%). (See In two comparative trials evaluating the efficacy of Fluconazole for the suppression of relapse of cryptococcal meningitis, a statistically significant increase was observed in median AST (SGOT) levels from a baseline value of 30 IU/L to 41 IU/L in one trial and 34 IU/L to 66 IU/L in the other. In an intravenous perinatal study in rats at 5 mg/kg, 20 mg/kg, and 40 mg/kg, dystocia and prolongation of parturition were observed in a few dams at 20 mg/kg (approximately 5 to 15 times the recommended human dose) and 40 mg/kg, but not at 5 mg/kg. An inadequate period of treatment may lead to recurrence of active infection. Fluconazole reduces the metabolism of tolbutamide, glyburide, and glipizide and increases the plasma concentration of these agents. (See Fluconazole increases the serum concentrations of theophylline. Ce médicament est disponible sous divers noms de marque ou sous différentes … There is no information regarding cross-hypersensitivity between Fluconazole and other azole antifungal agents. Most of the events were mild to moderate. (See In non-AIDS patients, side effects possibly related to Fluconazole treatment were reported in fewer patients aged 65 and older (9%, n =339) than for younger patients (14%, n=2240). Patients should have their blood pressure monitored continuously.Fluconazole may enhance the serum concentration of methadone. There was no change in cardiac repolarization as measured by Holter QTc intervals. Patients with esophageal candidiasis should be treated for a minimum of three weeks and for at least 2 weeks following the resolution of symptoms.For the treatment of acute cryptococcal meningitis, the recommended dosage is 12 mg/kg on the first day, followed by 6 mg/kg once daily. With this scheme it is assumed that the signs should improve within a few weeks. Of the most frequently reported (>1%) side effects, rash, vomiting, and diarrhea occurred in greater proportions of older patients. The mean ± SD increase in AUC was 20% ± 32% (range: –27 to 104%). Ask your doctor for tips on what you can do to help prevent vaginal yeast infections.If you get a vaginal yeast infection, you may have any of the following symptoms:Do not take Fluconazole if you take certain medicines. After the administration of cimetidine, there was a significant decrease in Fluconazole AUC and CConcomitant oral administration of 100 mg Fluconazole and 50 mg hydrochlorothiazide for 10 days in 13 normal volunteers resulted in a significant increase in Fluconazole AUC and CAdministration of a single oral 200 mg dose of Fluconazole after 15 days of rifampin administered as 600 mg daily in eight healthy male volunteers resulted in a significant decrease in Fluconazole AUC and a significant increase in apparent oral clearance of Fluconazole. Terfenadine acid metabolite AUC increased 36% ± 36% (range: 7 to 102%) from Day 8 to Day 15 with the concomitant administration of Fluconazole. Elevated fentanyl concentration may lead to respiratory depression.Fluconazole can increase halofantrine plasma concentration due to an inhibitory effect on CYP3A4.The risk of myopathy and rhabdomyolysis increases when Fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin. (See Plasma zidovudine concentrations were determined on two occasions (before and following Fluconazole 200 mg daily for 15 days) in 13 volunteers with AIDS or ARC who were on a stable zidovudine dose for at least two weeks. The structural formula … On the first day of dosing, Fluconazole increased the midazolam AUC and CA second randomized, double-dummy, placebo-controlled, cross-over study in three phases was performed to determine the effect of route of administration of Fluconazole on the interaction between Fluconazole and midazolam.