A randomized, double-blind, superiority-design clinical trial of lorazepam versus intravenous diazepam in 273 pediatric patients ages 3 months to 17 years failed to establish the efficacy of lorazepam for the treatment of status epilepticus. Renal function must be monitored carefully in such cases and if deterioration is found discontinuation of the treatment should be considered (see section 4.4). Eur. Nimodipine is metabolised via the cytochrome P450 3A4 system. In chronic repeat dose toxicity studies in dogs, doses of 1 and 2.5 mg/kg/day were shown to be tolerated without adverse effect. The prescriber should be aware that these figures cannot be used to predict the frequency of adverse events in the course of usual medical practice where patient characteristics and other factors may differ from those prevailing during clinical studies. Published studies in animals demonstrate that the use of anesthetic agents during the period of rapid brain growth or synaptogenesis results in widespread neuronal and oligodendrocyte cell loss in the developing brain and alterations in synaptic morphology and neurogenesis. Since tolerance for CNS depressants will be diminished in the presence of lorazepam injection, these substances should either be avoided or taken in reduced dosage. b. However, this is unlikely to be of clinical relevance in patients receiving Nimotop Solution. The overall incidence of pain and burning in patients was about 17% (146/859) in the immediate postinjection period and about 1.4% (12/859) at the 24-hour observation time.
It involves observation and management of all parameters critical to maintaining vital function and the capacity to provide support of those functions as required. The molecular weight is 321.16, and the C.A.S. Limited information derived from patients who were discharged the day after receiving injectable lorazepam showed one patient complained of some unsteadiness of gait and a reduced ability to perform complex mental functions.
Nimodipine capsules are formulated as soft gelatin capsules for oral adminis… Inpatient endoscopic procedures require adequate recovery room observation time. The half-life for nimodipine is between 1.1 and 1.7 hours. The intended effects of the recommended adult dose of lorazepam injection usually last 6 to 8 hours. For the first two hours of treatment 1 mg of nimodipine, i.e. It may be necessary to increase the dose of lorazepam in female patients who are concomitantly taking oral contraceptives (see also Concurrent administration of lorazepam (2 mg intravenously) with probenecid (500 mg orally every 6 hours) to 9 healthy volunteers resulted in a prolongation of lorazepam half-life by 130% and a decrease in its total clearance by 45%. Clear yellow sterile solution for intravenous use. Sedatives, tranquilizers and narcotic analgesics may produce a more prolonged and profound effect when administered along with injectable lorazepam. Simultaneous intravenous administration of beta-blockers may lead to mutual potentiation of negative inotropic action going as far as decompensated heart failure Renal function can deteriorate if potentially nephrotoxic drugs (e.g. This is most likely to occur when greater than 0.05 mg/kg is given and when narcotic analgesics are used concomitantly with the recommended dose (see As with all benzodiazepines, paradoxical reactions may occur in rare instances and in an unpredictable fashion (see There have been reports of possible propylene glycol toxicity (e.g., lactic acidosis, hyperosmolality, hypotension) and possible polyethylene glycol toxicity (e.g., acute tubular necrosis) during administration of lorazepam injection at higher than recommended doses. Patients should be informed of the pharmacological effects of the drug, including sedation, relief of anxiety, and lack of recall, the duration of these effects (about 8 hours), and be apprised of the risks as well as the benefits of therapy.
The amount of benzyl alcohol from medications is usually considered negligible compared to that received in flush solutions containing benzyl alcohol. At doses of 40 mg/kg orally or 4 mg/kg intravenously and higher, there was evidence of fetal resorption and increased fetal loss in rabbits which was not seen at lower doses. In the event of acute overdosage, treatment with Nimotop must be discontinued immediately. If there is a marked fall in blood pressure, dopamine or noradrenaline can be administered intravenously. There is no added beneficial effect from the addition of scopolamine to injectable lorazepam, and their combined effect may result in an increased incidence of sedation, hallucination and irrational behavior. This effect may take the form of excessive sleepiness or drowsiness and, on rare occasions, interfere with recall and recognition of events of the day of surgery and the day after. It involves observation and management of all parameters critical to maintaining vital function and the capacity to provide support of those functions as required.