Thyroid hormones may ↓ therapeutic effects.• For rapid effect, a larger initial loading/digitalizing dose should be given in several divided doses over 12-24 hr.
Osteoarthritis or rheumatoid arthritis: 1,200–3,200 mg/day PO (300 mg qid or 400, 600, 800 mg tid or qid; individualize dosage. Take your digoxin regularly even when you are feeling well. Therapeutic Effects: Increased cardiac output (positive inotropic effect) and slowing of the heart rate (negative chronotropic effect).Contraindicated in: Hypersensitivity; Uncontrolled ventricular arrhythmias; AV block (in absence of pacemaker); Idiopathic hypertrophic subaortic stenosis; Constrictive pericarditis; Known alcohol intolerance (elixir only).Drug-Drug: Thiazide and loop diuretics, piperacillin , ticarcillin, amphotericin B, corticosteroids, and excessive use of laxatives may cause hypokalemia which may ↑ risk of toxicity. Atrial fibrillation and atrial flutter (slows ventricular rate).
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Heart failure. Withhold dose and notify health care professional if pulse rate is <60 bpm in an adult, <70 bpm in a child, or <90 bpm in an infant. Drug Intell Clin Pharm 1983 Apr;17(4):286-8.
able to confirm that the correct medication has been dispensed if they require a
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Advise patient to notify health care professional of this medication regimen before treatment. Hypokalemia, hypomagnesemia, or hypercalcemia may make the patient more susceptible to digitalis toxicity. If the patient's response necessitates a change from the calculated loading dose of digoxin, then calculation of the maintenance dose should be based upon the amount actually given. abroad carry an adequate supply of their medications along with a list of the
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. medications they are taking by both generic and brand name, so that they will be
Maintain adequate potassium in diet. Because digoxin and other medications also are known by different trade names
Digoxin belongs to the class of medicines called digitalis glycosides. in countries outside the U.S., ISMP recommends that patients who are traveling
Maintain adequate hydration. Your doctor will occasionally ask you to have some blood tests. The effect of ibuprofen on serum digoxin concentrations. In a small percentage (10%) of patients gut bacteria metabolize digoxin to inactive compounds; macrolide anti-infectives (erythromycin, azithromycin, clarithromycin), tetracyclines, by killing these bacteria, will cause ↑ levels and toxicity; dose may need to be ↓ for up to 9 weeks. Do not double doses. High Alert Medication: This medication bears a heightened risk of causing significant patient harm when it is used in error.Increases the force of myocardial contraction. It is used to improve the strength and efficiency of the heart, or to control the rate and rhythm of the heartbeat. We review …
Bleeding time prolonged when NSAIDs are taken especially with high protein bound anticoaugulants like warfarin. Digoxin has a narrow therapeutic margin and potentially life-threatening cardiac adverse effects. Prolongs refractory period of the AV node. Some drug combinations can aggravate the cardiac adverse effects of digoxin, or reduce its efficacy. Report GI discomfort. For patients with AF and atrial flutter, digoxin works best when a high dose is given as an initial loading dose (rapid digitalisation). 2.Jorgensen HS, Christensen HR, Kampmann JP. Tablets: Initial: 500 to 750 mcg usually produces a detectable effect in 0.5 to 2 hours with a maximal effect in 2 to 6 hours. Do not discontinue medication without consulting health care professional. Pedi: Neonates may have falsely elevated serum digoxin concentrations due to a naturally occurring substance chemically similar to digoxin.Geri: Older adults may be toxic even when serum concentrations are within normal range; assess for clinical symptoms of toxicity even when serum levels are normal.• Therapeutic serum digoxin levels range from 0.5-2 ng/mL. This product is available in the following dosage forms:Portions of this document last updated: Aug. 01, 2020Copyright © 2020 IBM Watson Health. However, digoxin levels should always be interpreted taking into account what effects the drug in … © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). subtherapeutic dosing.